Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics?‡ C. Madjdpour, N. Dettori, P. Frascarolo, M.

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Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics?‡ C. Madjdpour, N. Dettori, P. Frascarolo, M. Burki, M. Boll, A. Fisch, T. Bombeli, D.R. Spahn British Journal of Anaesthesia Volume 94, Issue 5, Pages 569-576 (May 2005) DOI: 10.1093/bja/aei108 Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 1 Time-course of plasma coagulation parameters: PT (a), aPTT (b), functional vWF activity (c) and antigenic vWF concentration (d). HES was infused over 30 min and PT, aPTT, vWF activity and antigenic vWF concentration was determined before [baseline (BL); arrow] and 5, 60, 120, 240 and 1440 min after the end of the infusion (0 min). Results are mean (sd). *Solution effect of HES 500 vs HES 130 (Psol HES 500) and HES 900 vs HES 130 (Psol HES 900) as determined by two-way anova. British Journal of Anaesthesia 2005 94, 569-576DOI: (10.1093/bja/aei108) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 2 Time-course of the main TEG parameters: reaction time (r) (a), coagulation time (k) (b), maximal amplitude (MA) (c), angle (α) (d) and coagulation index (CI) (e). HES was infused over 30 min and TEG was determined before [baseline (BL); arrow] and 5, 60, 120, 240 and 1440 min after the end of the infusion (0 min). Results are mean (sd). *Solution effect of HES 500 vs HES 130 (Psol HES 500) and HES 900 vs HES 130 (Psol HES 900) as determined by two-way anova. British Journal of Anaesthesia 2005 94, 569-576DOI: (10.1093/bja/aei108) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 3 Pharmacokinetic modelling. The quality of fit between observed plasma concentration data and predicted data according to the chosen two-compartment model was analysed by linear regression analysis (a) and residual plot analysis (b). Conc.=concentration. British Journal of Anaesthesia 2005 94, 569-576DOI: (10.1093/bja/aei108) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 4 Time-course of serum HES concentration (a) and molecular weight (b). Insert in a shows the semi-logarithmic plot of concentration vs time. Results are mean (sd). *Solution effect of HES 500 vs HES 130 (Psol HES 500) and HES 900 vs HES 130 (Psol HES 900) as determined by two-way anova. British Journal of Anaesthesia 2005 94, 569-576DOI: (10.1093/bja/aei108) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 5 Blood (a–c) and plasma (d–f) viscosity measurements at shear rates ( γ ˙ ) of 1 s−1 (a, d), 4 s−1 (b, e) and 128 s−1 (c, f). Results are mean (sd). *Solution effect of HES 500 vs HES 130 (Psol HES 500) and HES 900 vs HES 130 (Psol HES 900) as determined by two-way anova. BL (arrow) denotes baseline. British Journal of Anaesthesia 2005 94, 569-576DOI: (10.1093/bja/aei108) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions