The “Aspirin” of the New Millennium: Cyclooxygenase-2 Inhibitors

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Presentation transcript:

The “Aspirin” of the New Millennium: Cyclooxygenase-2 Inhibitors Navtej S. Buttar, MBBS, Kenneth K. Wang, MD Mayo Clinic Proceedings Volume 75, Issue 10, Pages 1027-1038 (October 2000) DOI: 10.4065/75.10.1027 Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Pathologic and biologic functions of cyclooxygenase (COX)-2. Expression of COX-2 is restricted under basal conditions, but it can be induced substantially during inflammation, repair, and neoplasia. COX-l is expressed constitutively and maintains normal physiologic functions of the cells in most tissues, but in a few situations, COX-l may also be induced. Both isoforms convert arachidonic acid to prostaglandin (PO) H2. Depending on the site and circumstances of expression, the final PO product may vary. On a scale of 1+ to 3+ in which 1+ is minimal and 3+ is maximal. TX = thromboxane. Mayo Clinic Proceedings 2000 75, 1027-1038DOI: (10.4065/75.10.1027) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Potential role of cycIooxygenase (COX)-2 in carcinogenesis. Induction of COX-2 in neoplastic tissue can potentially promote carcinogenesis by modifying prostaglandin profile, immune response, and carcinogen metabolism. Mayo Clinic Proceedings 2000 75, 1027-1038DOI: (10.4065/75.10.1027) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions