LMNB1 overexpression suppresses oligodendrocyte-specific genes.

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LMNB1 overexpression suppresses oligodendrocyte-specific genes. LMNB1overexpression suppresses oligodendrocyte-specific genes. Luciferase reporter assays for the (A) NeuroD promoter in neuronal (C17.2) cells, (B) GFAP promoter in glial (N20.1) cells, and the (C) MBP, (D) PLP and (E) MOG promoters in glial (N20.1) cells. Relative promoter activities for cells co-transfected with either a vector or a construct containing cDNA encoding LMNB1 (LB1) are shown. Cells were grown at 34°C for (B) or 39°C for (C-E). *P<0.05, ** P<0.01. Shu-Ting Lin, and Ying-Hui Fu Dis. Model. Mech. 2009;2:178-188 ©2009 by The Company of Biologists Limited