LIMK1 inhibition protects against Aβ-induced neuronal hyperexcitability. LIMK1 inhibition protects against Aβ-induced neuronal hyperexcitability. (A) Representative.

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Presentation transcript:

LIMK1 inhibition protects against Aβ-induced neuronal hyperexcitability. LIMK1 inhibition protects against Aβ-induced neuronal hyperexcitability. (A) Representative bright-field image of primary hippocampal neuron cultures grown on a MEA plate. (B) Representative traces (left) and raster plots from three units (right) after exposure to DMSO, Aβ42, SR7826, or SR7826 and Aβ42. N = 17 to 24 wells per condition, which includes four to six neurons per well from three independent cultures. (C and D) Mean action potential frequency (C) and mean bursts frequency (D) over baseline in hippocampal neurons treated with DMSO, Aβ42, or SR7826 with or without Aβ42. Data are means ± SEM of three experiments. ***P < 0.001 [actual P = 0.0009 (C) and 0.0003 (D)] and **P < 0.01 [actual P = 0.0062 (C) and 0.0016 (D)] by one-way ANOVA with Šidák’s test. Benjamin W. Henderson et al., Sci. Signal. 2019;12:eaaw9318 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works