Fig. 4 Restoration of MTAP expression produces heterogeneous effects on metabolism. Restoration of MTAP expression produces heterogeneous effects on metabolism.

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Fig. 4 Restoration of MTAP expression produces heterogeneous effects on metabolism. Restoration of MTAP expression produces heterogeneous effects on metabolism. (A) Western blot validation of lentiviral ectopic expression of MTAP (compared to GFP control) in MTAP−/− cell lines. (B) Integrated intensity values of relative MTA metabolite levels in MTAP- or GFP-infected cell lines. (C) Volcano plots of each cell line, showing fold change values of metabolites between MTAP-infected and GFP-infected isogenic pairs. P values obtained using Student’s t test. IMP, inosine 5′-monophosphate; CDP, cytidine 5′-diphosphate. (D) Validation of nutrient restriction using integrated intensity values of the respective nutrient (left) and fold change values of MTA metabolite levels in complete/restricted culture conditions (right). (E) Number of significantly altered (P < 0.05, Student’s t test) metabolites in MTAP-expressing lines compared to GFP controls. (F) Fraction of significantly altered (P < 0.05, Student’s t test) metabolites that are related (i.e., within five reactions) or unrelated to the indicated nutrient. Sydney M. Sanderson et al. Sci Adv 2019;5:eaav7769 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).