Pathogen-specific IgG antibody levels in immunodeficient patients receiving immunoglobulin replacement do not provide additional benefit to therapeutic.

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Presentation transcript:

Pathogen-specific IgG antibody levels in immunodeficient patients receiving immunoglobulin replacement do not provide additional benefit to therapeutic management over total serum IgG Ignatius Chua, MBChB, MRCP, Macarena Lagos, MD, Bambos M. Charalambous, PhD, Sarita Workman, RN, MSc, Ronnie Chee, MBBS, MRCP, MRCPath, Bodo Grimbacher, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 6, Pages 1410-1411 (June 2011) DOI: 10.1016/j.jaci.2011.01.035 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Correlation of total IgG (g/L) levels with pathogen-specific IgG levels. A total of 75 individual antibody level results were taken from 62 patients. Samples were taken 2 to 4 weeks after the patient’s last immunoglobulin infusion. Each individual sample was analyzed for total IgG, PCP-Ab, HIB-Ab, and TET-Ab. A, Total IgG and PCP-Ab. B, Total IgG and HIB-Ab. C, Total IgG and TET-Ab. On each graph, the linear regression line is shown with 95% CI in dotted lines. Journal of Allergy and Clinical Immunology 2011 127, 1410-1411DOI: (10.1016/j.jaci.2011.01.035) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Scatter plot of PCP-Ab (A) and HIB-Ab (B) results grouped according to 3 levels of total IgG (>9.0 g/L, 7.0-9.0 g/L, and <7.0 g/L). The cutoffs for optimal/suboptimal levels for PCP-Ab (50 mg/L) and HIB-Ab (1 mg/L) are shown by a dotted line. Journal of Allergy and Clinical Immunology 2011 127, 1410-1411DOI: (10.1016/j.jaci.2011.01.035) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions