Decreased GLP-1 receptor expression in islets after exposure to high glucose. Decreased GLP-1 receptor expression in islets after exposure to high glucose.

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Fig Summary of physiological function of the incretins GLP-1 and GIP on islet cells The Islets of Langerhans, Islam, Md. Shahidul (Ed.) ISBN: ,

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Decreased GLP-1 receptor expression in islets after exposure to high glucose. Decreased GLP-1 receptor expression in islets after exposure to high glucose. A and B: Glucose or saline was infused in conscious rats for 4 days. GLP-1 and GIP receptor mRNA levels for each animal were examined 4 days after infusion. C and D: Isolated rat islets were exposed to various concentrations of glucose (5–30 mmol/l) for 2 days, and GLP-1 and GIP receptor mRNA levels were examined (n = 4 independent experiments). Representative gels show the receptor and internal control (TBP [TATA-binding protein]) to which the values were normalized in the graphs. *P < 0.05; **P < 0.01. Gang Xu et al. Diabetes 2007;56:1551-1558 ©2007 by American Diabetes Association