Schematic diagram of miRNA regulation of the Hippo signalling pathway with multiple inputs and key interactions with HIF1α. Schematic diagram of miRNA.

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Schematic diagram of miRNA regulation of the Hippo signalling pathway with multiple inputs and key interactions with HIF1α. Schematic diagram of miRNA regulationof the Hippo signalling pathway with multiple inputs and key interactions with HIF1α. Vertebrate orthologue proteins are shown in parentheses. Adapted in part from miRPath v.3 KEGG pathway (see Materials and Methods). With Drosophilamelanogaster used as the reference species, 12 of the 21 differentially expressed miRNA homologues, miR-1-3p, let-7-3p, miR-8-3p, miR-87-3p, miR-283-5p, miR-317-3p, miR-12-5p, miR-279-3p, miR-133-3p, miR-305-5p, miR-190-5p and bantam-3p, were identified as statistically significant regulators of the Hippo signalling pathway (P=8.70e−07). Simon G. English et al. J Exp Biol 2018;221:jeb190579 © 2018. Published by The Company of Biologists Ltd