Change in markers of glycometabolism and cardiovascular risk profile. Change in markers of glycometabolism and cardiovascular risk profile. Absolute changes in (95% CI) the metformin and placebo groups in glycated hemoglobin (HbA1c) concentration (A), insulin levels (B), body weight (C), total cholesterol (D), low-density lipoprotein (LDL)-cholesterol (E), and high-density lipoprotein (HDL)-cholesterol (F) were analyzed using analysis of covariance. Chris P H Lexis et al. BMJ Open Diab Res Care 2015;3:e000090 ©2015 by American Diabetes Association