Pol II pausing over other gene classes.

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Pol II pausing over other gene classes. Pol II pausing over other gene classes. . (A) NET-seq density plots (control and Ssrp1 KD group) of down-regulated genes split by FACT-bound status (non-SSRP1 and SSRP1 targets). Solid lines indicate mean values, whereas the shading represents the 95% confidence interval. (B) Boxplots assessing fold change (Ssrp1 KD versus control) in antisense transcription (NET-seq) in a window 1,000 bp upstream of the TSS. The Welch's two-sided t test was used to calculate significance between non-SSRP1 and SSRP1 targets. (C) Same as (A) but for genes whose expression does not change (unchanged genes) in the Ssrp1 KD condition. (D) Same as (B) but for unchanged genes. Constantine Mylonas, and Peter Tessarz LSA 2018;1:e201800085 © 2018 Tessarz and Mylonas