MicroPET and CCD imaging of β-cells in MIP-TF mice.

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MicroPET and CCD imaging of β-cells in MIP-TF mice. MicroPET and CCD imaging of β-cells in MIP-TF mice. Representative CCD and microPET/CT images of a MIP-TF mouse before (A–E and K) and after (F–J and L) being rendered diabetic with STZ are shown. A and F show CCD images before, and after, STZ treatment, respectively. The same mouse was injected with [18F]FHBG and imaged 6 h later with microPET/CT. Two hours before microPET, Fenestra was injected to provide spleen and liver contrast, so we could identify those organs in the CT images. B–D: Coronal CT scan (B), coronal microPET scan (C), and merged microPET/CT (D) before STZ treatment. G–I: Coronal CT scan (G), coronal microPET scan (H), and merged microPET/CT (I) after the mouse was rendered diabetic with STZ. E and J: Sagital microPET/CT images before and after STZ (respectively). K and L: Transverse microPET/CT images before and after STZ. “L” points to liver, “S” points to spleen, and “P” points to pancreas. Three mice were imaged before and after being rendered diabetic by STZ administration, and the change in [18F]FHBG retention in the pancreas region of individual mice is shown (M). All microPET/CT images are on the same scale. In other experiments, the uptake of [18F]FHBG in the pancreas region as measured by microPET imaging 5 h after probe injection was plotted against bioluminescence signal as measured by BLI for individual animals (N). A significant linear correlation (R2 = 0.41) was found for [18F]FHBG uptake and bioluminescence (P < 0.05). (A high-quality color representation of this figure is available in the online issue.)‏ Jing Yong et al. Diabetes 2011;60:1383-1392 ©2011 by American Diabetes Association