Market America World Conference – February 2016 by Dr. Steven Lamm &

Learn How to… …Defend Your Health

Isotonix®

HEART MUSCLES Isotonix® BRAIN EYES VEINS SKIN

Build mass… …but don’t lose it!

NEW STUDY : Muscle Function / Sarcopenia Defend Your Muscles NEW STUDY : Muscle Function / Sarcopenia 64 subjects with loss of muscle mass with age (sarcopenia)  70-78 years of age with high oxidative stress (>320 Carr U) 2 months Belcaro G. et al, in submission

Pycnogenol® improves muscular function % improvement in muscular function in 8 weeks * * * * * * *p<0.05 vs baseline and controls Belcaro G. et al, in submission

Pycnogenol® decreases proteinuria* *a marker of muscular loss in urine Control Group * Pycnogenol® *p<0.05 vs baseline and controls Belcaro G. et al, in submission

Defend Your Brain Clinical Study with 77 subjects 55-70 years of age with high oxidative stress Belcaro G. et al, J Neurosurg Sci. 2015 submitted

Pycnogenol® improves cognitive functions % improvement of cognitive functions (VASL) after 12 months * * * * * * * *p<0.05 Belcaro G. et al, J Neurosurg Sci. 2015 submitted

Defend Your Eyes Clinical Study with 77 subjects 9 months Aim prevention of a new retinal vein thrombosis episode Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125.

Pycnogenol® and retinal vein thrombosis * *p<0.05 Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125.

Pycnogenol® effect on retinal edema * *p<0.05 Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125.

Pycnogenol® effect on visual acuity 20/25 * 20/32 20/40 *p<0.05 Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125.

Defend Your Skin Clinical Study with 20 menopausal women Aged 55-68 years, Skin type II or III Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17.

Pycnogenol® effects on melanogenesis start 12 weeks start 12 weeks 20 healthy postmenopausal women 75 mg/day Pycnogenol for 12 weeks Pycnogenol significantly improved hydration and elasticity of skin. These effects were most pronounced in women presenting with dry skin conditions prior to the start of supplementation. significant increase in the mRNA expression of hyaluronic acid synthase-1 (HAS- 1), an enzyme critically involved in the synthesis of hyaluronic acid, and a noticeable increase in gene expression involved in collagen de novo synthesis UVA-1 radiation 100 J/cm2 (area of 4 cm2) Treatment regimen: 75 mg oral Pycnogenol® for 12 weeks Biopsies at start and at 12 weeks before and after UV radiation mRNA expression of MITF, TRP1, MART, Tyrosinase & Loricrin Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17.

Pycnogenol® inhibits UVA induced hyperpigmentation -75% -51% -67% -67% Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17.

Pycnogenol® increases gene expression of loricrin Loricrin, a major component of the cornified cell in the stratum corneum accounts for much of cornified envelope mechanical resistance. X 2.5 P=0.017 Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17.

Pycnogenol® compared to European OTC for venous health

Example : Chronic Venous Insufficiency Pycnogenol® vs. Antistax® Ankle Swelling Resting Flux Ankle Circumference Pain Edema Compression -0% -0% -2% -3% -6% -11% -20% -27% -41% -48% -48% -86% *p<0.05 vs baseline, N=166, Antistax® 720 mg/day, Pycnogenol® 100mg/day Belcaro, G. (2015). " International Journal of Angiology.

Pycnogenol® more effective than Antistax® Signs and symptoms of CVI Edema Capillary filtration Blood flow Microcirculation Oxidative stress And more Belcaro, G. (2015). " International Journal of Angiology.

Isotonix® Helps Defend Your Health

Defend Your Health

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