Relative potency of Drugs

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Presentation transcript:

Relative potency of Drugs Drug potency is related to efficacy Relates the concentration of a drug required to produce a given response Consider two drugs - DRUG A & DRUG B These drugs act on the same receptors But have different potencies

Log10 conc v response to show potency Drug A Drug B 150 100 Response (mm) 50 -8 -7 -6 -5 -4 -3 Log conc agonist (M)

Calculation of Potency Which of these drugs is more potent? Calculate EC50 Concentration required to give 50% of the maximum response Rather “old fashioned term” pD2 = -log EC50

Obtaining EC50 values Response (mm) Log conc agonist (M) MAX 50% 150 100 Response (mm) 50% 50 -8 -7 -6 -5 -4 -3 Log conc agonist (M)

Calculation of potency ratio of drugs A and B EC50 drug B = 23.07 µM or 2.31 x 10-5 M EC50 drug A = 0.18 µM or 1.8 x 10-7 M Relative potency = EC50 drug B EC50 drug A = 23.07 0.18 drug A is 128 times more potent than drug B

Recommended Reading Potency Pharmacology, 5th Ed: Page 11 Basic and Clinical Pharmacology Online Book: Section I, Chapter 2, Signalling Mechanisms and Drug Action