Volume 378, Issue 9809, Pages (December 2011)

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Volume 378, Issue 9809, Pages 2081-2087 (December 2011) Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial Prof Sir John Burn, MD, Prof Anne-Marie Gerdes, MD, Prof Finlay Macrae, MD, Prof Jukka-Pekka Mecklin, MD, Gabriela Moeslein, MD, Sylviane Olschwang, MD, Prof Diane Eccles, MD, Prof D Gareth Evans, MD, Prof Eamonn R Maher, MD, Lucio Bertario, MD, Marie- Luise Bisgaard, MD, Prof Malcolm G Dunlop, MD, Judy WC Ho, MD, Prof Shirley V Hodgson, MD, Prof Annika Lindblom, MD, Prof Jan Lubinski, MD, Prof Patrick J Morrison, MD, Victoria Murday, MD, Prof Raj Ramesar, PhD, Lucy Side, MD, Prof Rodney J Scott, PhD, Prof Huw JW Thomas, PhD, Prof Hans F Vasen, MD, Gail Barker, Gillian Crawford, Faye Elliott, Mohammad Movahedi, PhD, Kirsi Pylvanainen, Juul T Wijnen, PhD, Prof Riccardo Fodde, PhD, Prof Henry T Lynch, MD, Prof John C Mathers, PhD, Prof D Timothy Bishop, PhD The Lancet Volume 378, Issue 9809, Pages 2081-2087 (December 2011) DOI: 10.1016/S0140-6736(11)61049-0 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile RS=resistant starch. RSP=resistant starch placebo. CRC=colorectal cancer. The Lancet 2011 378, 2081-2087DOI: (10.1016/S0140-6736(11)61049-0) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 2 Time to first colorectal cancer in participants randomly assigned to aspirin compared with those assigned to aspirin placebo (A) Kaplan-Meier analysis, adjusted for sex. (B) Kaplan-Meier analysis restricted to participants who had taken the intervention for 2 years or more, adjusted for sex. Each point on the plots shows the estimated cumulative incidence by years of follow-up; error bars show 95% CIs. HR=hazard ratio. CRC=colorectal cancer. The Lancet 2011 378, 2081-2087DOI: (10.1016/S0140-6736(11)61049-0) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 3 Time to first Lynch syndrome cancer in participants randomly assigned to aspirin compared with those assigned to aspirin placebo Kaplan-Meier analysis restricted to participants who had taken the intervention for 2 years or more, adjusted for sex. Each point on the plot shows the estimated cumulative incidence by years of follow-up; error bars show 95% CIs. HR=hazard ratio. The Lancet 2011 378, 2081-2087DOI: (10.1016/S0140-6736(11)61049-0) Copyright © 2011 Elsevier Ltd Terms and Conditions