The notochord and the peri-notochordal basement membrane.

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Presentation transcript:

The notochord and the peri-notochordal basement membrane. The notochord and the peri-notochordal basement membrane. (A) Schematic diagram of a transverse section through the trunk of a vertebrate embryo, depicting the tissue organization and signaling during embryogenesis. The notochord cells (no) secrete Shh (arrows) and a gradient of Shh signal is established in the dorso-ventral axis. This signal is critical for the proper patterning of the surrounding tissues, including the neural tube (nt), the floor plate (fp), the somites (ss) and the dorsal aorta (da). The dashed line marks the midline of the dorso-ventral axis. (B) Transmission electron micrograph of the peri-notochordal basement membrane of a zebrafish embryo at 30 h post-fertilization. The peri-notochordal basement membrane is composed of three parts: the inner (i) basal lamina, surrounded by a medial (m) layer of collagen fibrils that run parallel to the notochord, and an outer (o) granular layer of loosely organized ECM that is mostly oriented in a perpendicular manner to the notochord. The peri-notochordal sheath counteracts the pressure generated by intracellular vacuoles of the notochordal cells (v), providing rigidity and correct stiffness to this structure. Scale bar: 10 μm. The image in B has been adapted with permission from Corallo et al., 2013. Valeria Trapani et al. J Cell Sci 2017;130:3203-3211 © 2017. Published by The Company of Biologists Ltd