Model of the Ang-1 pathway in early lung development.

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Model of the Ang-1 pathway in early lung development. Model of the Ang-1 pathway in early lung development. Proposed model of the Ang-1 pathway in early lung development (E12.5 to E15.5) hypothesizes that Ang-1 (red) secreted by the distal lung bud acts in a trophic fashion on progenitor vascular endothelial cells expressing receptor Tie-2 (green) in the mesenchyme to induce downstream signaling and stabilization of the nascent vasculature. In later development (E18.5 to postnatal), the relationship between Ang-1 and Tie-2 contributes to the stabilization of the primary blood vessels associated with the central airways in the maturing lungs. PN, post-natal. Adrienne Grzenda et al. Dis. Model. Mech. 2013;6:106-114 © 2012. Published by The Company of Biologists Ltd