Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after.

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Presentation transcript:

Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after in vitro fertilization: a pilot study Erkan Buyuk, M.D., Obehi A. Asemota, M.D., Zaher Merhi, M.D., Maureen J. Charron, Ph.D., Dara S. Berger, Ph.D., Athena Zapantis, B.S., Sangita K. Jindal, Ph.D. Fertility and Sterility Volume 107, Issue 3, Pages 632-640.e3 (March 2017) DOI: 10.1016/j.fertnstert.2016.12.023 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Correlation between body mass index (BMI) and serum (A) monocyte chemotactic protein-1 (MCP-1) (r = 0.4, P=.01), (B) granulocyte colony stimulating factor (G-CSF) (r = 0.43, P=.007), (C) catalase activity (r = 0.36, P=.04), and (D) C-reactive protein (CRP) (r =0.53, P=.0006). Fertility and Sterility 2017 107, 632-640.e3DOI: (10.1016/j.fertnstert.2016.12.023) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Correlation between body mass index (BMI) and follicular fluid monocyte chemotactic protein-1 (MCP-1) levels (r = 0.45, P=.003). Fertility and Sterility 2017 107, 632-640.e3DOI: (10.1016/j.fertnstert.2016.12.023) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Receiver operating characteristic (ROC) curve analysis for predicting failure to achieve clinical pregnancy in all women for (A) serum monocyte chemotactic protein-1, (B) age, (C) serum monocyte chemotactic protein-1 after controlling for age, and in women with diminished ovarian reserve for (D) serum monocyte chemotactic protein-1. The ROC curve analysis of C-reactive protein for predicting failure to achieve clinical pregnancy in all women (E) and in women with diminished ovarian reserve (F). Fertility and Sterility 2017 107, 632-640.e3DOI: (10.1016/j.fertnstert.2016.12.023) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions