1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

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1018-NT-β-cell clusters protect mice from STZ-induced diabetes. 1018-NT-β-cell clusters protect mice from STZ-induced diabetes. A and B: Blood glucose and human C-peptide serum concentration in mice at ∼3 months after transplantation with 1018-NT-β-cell clusters at fasting and 3 h after refeeding (after food) (n = 9). C: Serum human proinsulin-to-insulin ratios of 1018-NT-β-cell clusters and human islets after 3 months of transplantation. (Each black dot or square indicates an individual mouse grafted with indicated cells.) D: Mouse C-peptide levels at 2 weeks after STZ treatment before and after glucose injection. E: Blood glucose levels of STZ-treated mice without transplantation (w/o Tx) (n = 3) and transplanted with 1018-NT-β-cell clusters (1018-NT-β) (n = 8) and with human islets (n = 3). F: Serum human C-peptide concentrations of STZ-treated mice at fasting and at 30 and 60 min after intraperitoneal glucose injection. G: Glucose tolerance test of STZ-treated mice without transplantation (n = 4) and transplanted with 1018-NT-β-cell clusters (n = 8) and with human islets (n = 3) in the fed state, the fasting state, and 30–90 min after glucose injection. H: Blood glucose levels of STZ-treated mice before and after grafts were removed (n = 2). *P < 0.05; **P < 0.01; ****P < 0.0001. Lina Sui et al. Diabetes 2018;67:26-35 ©2018 by American Diabetes Association