Otitis media in Edaraddswh/swh rats is associated with smaller auditory-tube submucosal glands (SMGs). Otitis media in Edaraddswh/swh rats is associated.

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Otitis media in Edaraddswh/swh rats is associated with smaller auditory-tube submucosal glands (SMGs). Otitis media in Edaraddswh/swh rats is associated with smaller auditory-tube submucosal glands (SMGs). (A) The prevalence of otitis media in Edaraddswh/swh rats is indicated by the proportion of affected bullae and increases significantly from P30 to P42 and P83-P85 compared with age-matched Edaraddswh/+ littermates. Data are represented as points. The number to the left of each data point indicates the number of Edaraddswh/swh bullae examined, and those to the right are for Edaraddswh/+ bullae. Frequency data were analysed using Fisher's exact tests. (B) Auditory-tube SMGs were smaller in Edaraddswh/swh than Edaraddswh/+ rats at the P21, P42 and P83-P85 time points. Two or three rats of each genotype were analysed at each time point. The area of each gland was measured in histological step sections and the right and left glands were measured separately. (C) In P83-P85 Edaraddswh/swh auditory-tube SMGs, the area occupied by PAS-positive acini is reduced, but this trend does not achieve statistical significance for AB-positive mucus. (D) Nasopharynx width increases with age, but median width is comparable between Edaraddswh/swh and Edaraddswh/+ for each time point. Data in graphs B-D are represented as points and the bar the median. Data in B and C were analysed with Mann–Whitney tests. Two-tailed tests were used throughout. ns, not significant (P>0.05); *P<0.05, **P<0.01. Jorge del-Pozo et al. Dis. Model. Mech. 2019;12:dmm037804 © 2019. Published by The Company of Biologists Ltd