RIPK3 Slams the Brake on Leukemogenesis

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development Xavier Morin, Yohanns Bellaïche Developmental Cell Volume.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors Kunyoo Shin, Agnes Lim, Chen.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

Neurogenin3 Is Sufficient for Transdetermination of Hepatic Progenitor Cells into Neo- Islets In Vivo but Not Transdifferentiation of Hepatocytes Vijay.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Of Brains and Blood: Developmental Origins of Glioma Diversity?

Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg

The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response

Intravascular Survival and Extravasation of Tumor Cells

Volume 1, Issue 1, Pages (June 2007)

Nomeda Girnius, Roger J. Davis Cancer Cell

Nicole R. Murray, Verline Justilien, Alan P. Fields Cancer Cell

mTOR Signaling in Melanoma: Oncogene-Induced Pseudo-Senescence?

An Alternative Sugar Fuels AML

Boosting Bacterial Metabolism to Combat Antibiotic Resistance

Christian Grommes, Anas Younes Cancer Cell

NAD+ Supplementation as a Novel Approach to cURIng HCC?

A Death Trap for Microglia

Data Triumph at C Cancer Cell

Exploiting the Hidden Treasure of Detained Introns

Elodie Pronier, Ross L. Levine Cancer Cell

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

No Need for Constant Help: Human IgG2 Antibodies Have an Autonomous Agonistic Activity for Immunotherapy of Cancer Anja Lux, Falk Nimmerjahn Cancer.

Tumor Evolution: A Problem of Histocompatibility

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

Tipping the Balancing ACT

Suppressing NFAT Increases VEGF Signaling in Hemangiomas

Daichi Inoue, Omar Abdel-Wahab Cancer Cell

Laurence Zitvogel, Guido Kroemer Cancer Cell

Embryos, Camera, Laser, Action!

Pseudokiller, Qu’est-ce que C’est?

Fibrinogen in the Nervous System: Glia Beware

Joanne M. Hildebrand, James M. Murphy Immunity

Apoptosis, Up the Ante Cancer Cell

Of Brains and Blood: Developmental Origins of Glioma Diversity?

ER Stress in Dendritic Cells Promotes Cancer

Life after MOMP Molecular Cell

Richard G. Carroll, Seamus J. Martin Cancer Cell

Autophagy Determines the Path on the TRAIL to Death

AML Therapy: Wake Up the Guardian and Cut Loose the Executioners

ESCRTing Necroptosis Cell

Alex Kentsis, A. Thomas Look Cell Stem Cell

Getting a gRIP on Flu by Casting the DAI

Splicing and Dicing MYC-Mediated Synthetic Lethality

Khalid S. Mohammad, Theresa A. Guise Cancer Cell

TFIID and MYB Share a Therapeutic Handshake in AML

Simón Méndez-Ferrer, María García-Fernández, Carlos L.F. de Castillejo

Volume 10, Issue 3, Pages (September 2006)

All Roads Lead to the Ribosome

c-Raf in KRas Mutant Cancers: A Moving Target

David Hubel and Torsten Wiesel

Ibrutinib Treatment of CLL: The Cancer Fights Back

Presentation transcript:

RIPK3 Slams the Brake on Leukemogenesis Francis Ka-Ming Chan Cancer Cell Volume 30, Issue 1, Pages 7-9 (July 2016) DOI: 10.1016/j.ccell.2016.06.017 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 RIPK3 and MLKL Mediate Cell Death and IL-1β Processing to Limit the Extent of FLT3-ITD-Induced Leukemogenesis In human AML, loss of RIPK3 and MLKL inhibit these processes, which results in a developmental block and enhanced survival of transformed immature progenitors. Cancer Cell 2016 30, 7-9DOI: (10.1016/j.ccell.2016.06.017) Copyright © 2016 Elsevier Inc. Terms and Conditions