Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver.

Slides:

Advertisements

Similar presentations

Effect of a 6-day icv ghrelin infusion (2.5 nmol/d) on cumulative food intake (A), body weight gain (B), food efficiency (C), and fat mass gain (D) Claudia.

Advertisements

Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity Sara Gry Vienberg, André Kleinridders, Ryo.

Volume 10, Issue 4, Pages (October 2009)

Volume 144, Issue 3, Pages e6 (March 2013)

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Key clinical efficacy outcomes for (A) hemoglobin A1c (HbA1c), (B) weight change. Key clinical efficacy outcomes for (A) hemoglobin A1c (HbA1c), (B) weight.

The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.

Volume 144, Issue 3, Pages e6 (March 2013)

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

Glucose homeostasis: roles of insulin, glucagon, amylin, and GLP-1.

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

Body weight and oral glucose tolerance in diet-induced obese rats at 5 weeks post-surgery. Body weight and oral glucose tolerance in diet-induced obese.

Voluntary but not forced exercise alters food consumption in mice.

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

A B * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * 105

I.c.v.‐injected AβOs induce increased food intake, hypothalamic expression of orexigenic neuropeptides but no hypothalamic cell degeneration AAccumulated.

Decreased weight and adiposity is transmissible via the gut microbiota

Central nervous system BDNF infusion fails to increase tissue glucose uptake in uncontrolled insulin-deficient diabetes. Central nervous system BDNF infusion.

Cellularity of epididymal adipose tissue.

Deletion of neuronal insulin receptor signaling reduces TG secretion, while the targeted knockout of insulin receptors restricted to the periphery increases.

Results for HbA1c (A), severe or BG-confirmed symptomatic hypoglycemia (B), change in body weight (C), daily total insulin dose (D), FPG (E), and nine-point.

Effect of insulin on hepcidin expression in HepG2 cells.

Body weight, blood glucose, and iron status in STZ-induced type 1 diabetic rats with or without insulin therapy. Body weight, blood glucose, and iron status.

Glucose, insulin, and AGE levels during an OGC before and after RT

A working hypothesis for insulin action in the brain.

Decreased GLP-1 receptor expression in islets after exposure to high glucose. Decreased GLP-1 receptor expression in islets after exposure to high glucose.

Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.

Plasma glucose (A) and glucose specific activity (B) during euglycemic clamp experiments. Plasma glucose (A) and glucose specific activity (B) during euglycemic.

Omental FFA production, calculated from the integrated lipolysis over the last 30 min of each insulin infusion period. Omental FFA production, calculated.

Glucose infusion rate required to maintain the hyperglycemic clamp during the experimental period in sedentary and exercised dogs receiving basal or elevated.

Liver AMPK is activated by oral administration of canagliflozin in mice, but this does not explain changes in RER. A: Phosphorylation of AMPK, ACC, and.

GLUT4 LXRE is required for downregulation of adipose GLUT4 mRNA during fasting and diet-induced obesity. GLUT4 LXRE is required for downregulation of adipose.

Smad3-KO adipose tissues have increased FA uptake and β-oxidation.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

Effect of berberine on white adipose tissue mass.

At 6 months of age, PPARγ deletion in late osteoblast/osteocyte controls glucose homeostasis by increasing metabolic rate and glucose uptake in WAT, BAT,

Insulin sensitivity in athletes and sedentary normal-weight and obese, young, and old individuals. Insulin sensitivity in athletes and sedentary normal-weight.

The effect of VSG on body weight and body fat in GLP-1r KO mice.

A: Chemical structure of pterosin A

Rapid improvement of glucose tolerance induced by PP

Metabolic parameters of Id1−/− and wild-type mice fed a standard chow diet (hatched bars and striped bars, respectively) or a high-fat diet (black bars.

Total plasma BCAA (A) and C3 and C5 acylcarnitine (AC) (B) concentrations in the basal state and during insulin infusion in obese subjects before and after.

CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured SGBS cells during adipocyte differentiation. CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured.

Caloric intake in lean and obese Zucker rats in response to systemic infusion of glucose alone (HG-HI protocol) or glucose with insulin (EuG-HI protocol).

Intracerebroventricular (ICV) insulin infusion increases TG secretion.

Effect of anandamide on blood glucose clearance and insulin sensitivity. Effect of anandamide on blood glucose clearance and insulin sensitivity. A: Intraperitoneal.

MϕRIP140KD mice show browning in vWAT.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

Food intake in response to central infusion of glucose (squares) or insulin (triangles) and in response to successive central infusion of insulin, insulin.

Insulin resistance and hepatic steatosis in ASKO mice.

Treatment of high-fat diet–fed mice with TTR-ASOs decreases circulating TTR and RBP4 levels, and improves insulin sensitivity. Treatment of high-fat diet–fed.

Effects of Rosi treatment on ASKO mice.

Effects of berberine on in vivo metabolism in two animal models of insulin resistance. Effects of berberine on in vivo metabolism in two animal models.

Metabolic effects of VSG in GLP-1r KO mice.

β-Cell–specific deletion of Phb2 renders mice diabetic.

Pioglitazone administration acutely inhibits insulin secretion and increases insulin clearance in Wistar rats. Pioglitazone administration acutely inhibits.

Mice lacking Y1 receptor in the hematopoietic compartment remain healthy under normal chow feeding conditions. Mice lacking Y1 receptor in the hematopoietic.

Pioglitazone administration acutely reduces whole-body energy expenditure in Wistar rats. Pioglitazone administration acutely reduces whole-body energy.

Effect of empagliflozin on efficacy parameters at week 18.

Exogenous RvD1 treatment attenuated EAN

(A) Mean glucose concentrations (standard error) over a 3-hour period in 21 placebo- and 15 pramlintide-treated patients with type 1 diabetes treated for.

Mean changes (standard error) from baseline in A1C (A and B) and body weight (C and D) for patients with type 1 (A and C) or type 2 (B and D) diabetes.

EPA+DHA supplementation does not alter body composition, body weight, or feed intake. EPA+DHA supplementation does not alter body composition, body weight,

Volume 14, Issue 9, Pages (March 2016)

Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.

Expression of IFN-λs, IFN-λR1, and IL-10R2 in Xenopus tissues after stimulation in vivo with poly(I:C). Expression of IFN-λs, IFN-λR1, and IL-10R2 in Xenopus.

Fig. 1. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. GDF15 is up-regulated with obesity, and AAV-GDF15.

Change in first-phase insulin response (A) and pancreas triglyceride content (B) in responders and nonresponders at baseline (hatched bars), after VLCD.

Hepatic triglyceride content (A), hepatic insulin resistance index (B), and hepatic VLDL1-triglyceride production (C) in responders and nonresponders at.

Fig. 3. Effects of SFN in mice with diet-induced diabetes.

Presentation transcript:

Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. A: Study protocol. MRT I–III indicate the time points where 1H-MRS measurements were performed. B: Liver fat content measured using 1H-MRS in anesthetized rats on days −3, 8, and 28. C: FA profiles from liver tissue harvested on day 30. Data are depicted as % change vs. vehicle-infused animals. D: Body weight. E: Food intake. F: Comparison of mRNA copy numbers of DNL genes in liver tissue samples from intracerebroventricular (ICV) insulin– or vehicle–treated rats. All error bars are SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. respective control group. n = 8/group. Thomas Scherer et al. Diabetes 2016;65:1511-1520 ©2016 by American Diabetes Association