Fig. 6 Integration of responsiveness to nutrient restriction determines quantitative impact of MTAP deletion on global metabolic networks. Integration.

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Fig. 6 Integration of responsiveness to nutrient restriction determines quantitative impact of MTAP deletion on global metabolic networks. Integration of responsiveness to nutrient restriction determines quantitative impact of MTAP deletion on global metabolic networks. (A) Number of significantly altered (P < 0.05, Student’s t test) metabolites for each cell line under each of the three nutrient restriction conditions. (B) Venn diagrams depicting overlap of average number of significantly altered related metabolites within a cell line for MTAP+/+ and MTAP−/− groups. (C) Number of significantly altered metabolites for each nutrient restriction, as determined by three separate statistical analyses as indicated. (D) Number of total unique significantly altered metabolites for each condition indicated. (E) AUC of top PCs that account for 70% of variance between either MTAP+/+ and MTAP−/− or control and restricted nutrient conditions. (F) Graphical summary illustrating that environment and cell identity shape the metabolome to a greater extent than MTAP status or tissue of origin. Sydney M. Sanderson et al. Sci Adv 2019;5:eaav7769 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).