Neurocranial cartilage patterns in wild-type and Hh-deficient larvae.

Slides:

Advertisements

Similar presentations

The role of hdac4 in zebrafish craniofacial development Vishesh Khanna University of Oregon PI: Prof. Charles Kimmel Mentor: Dr. April DeLaurier Hypothesis:

Advertisements

Axial Skeleton Skull Cephalization Neurocranium

Vishesh Khanna Kimmel Lab. Neurocranium Images from Kimmel et al

THORACIC CAGE Chapter 7. Thoracic Cage  Consists of thoracic vertebrae dorsally  Ribs are laterally positioned  Sternum and Costal Cartilage are anterior.

New tools for studying osteoarthritis genetics in zebrafish

Feng Liu, Maggie Walmsley, Adam Rodaway, Roger Patient Current Biology

FAF1, a Gene that Is Disrupted in Cleft Palate and Has Conserved Function in Zebrafish Michella Ghassibe-Sabbagh, Laurence Desmyter, Tobias Langenberg,

New tools for studying osteoarthritis genetics in zebrafish

Volume 135, Issue 5, Pages (November 2008)

Figure 5 Chp1 downregulation in zebrafish leads to CaP-MN, cerebellar, and movement defects rescued with WT, but not mutant CHP1 mRNA Chp1 downregulation.

Martin Gering, Roger Patient Developmental Cell

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node Xiaoyan M. Zhang, Miguel.

New tools for studying osteoarthritis genetics in zebrafish

Klaus B. Rohr, K.Anukampa Barth, Zoltán M. Varga, Stephen W. Wilson

Volume 21, Issue 4, Pages (April 2014)

Volume 29, Issue 2, Pages (April 2014)

Volume 4, Issue 2, Pages (August 2006)

Muscle Building Developmental Cell

Guozhu Ning, Xiuli Liu, Miaomiao Dai, Anming Meng, Qiang Wang

Volume 8, Issue 4, Pages (April 2005)

The GSL biosynthetic pathway is active in both germ line and follicle cells. The GSL biosynthetic pathway is active in both germ line and follicle cells.

PM analysis of wild-type E. coli K-12 and its rpoZ-defective mutant.

Volume 18, Issue 5, Pages (May 2010)

Naoyuki Fuse, Kanako Hisata, Alisa L. Katzen, Fumio Matsuzaki

Volume 95, Issue 7, Pages (December 1998)

Volume 6, Issue 2, Pages (August 2000)

Sonic hedgehog and vascular endothelial growth factor Act Upstream of the Notch Pathway during Arterial Endothelial Differentiation Nathan D. Lawson,

Genetic perturbations using dad44C10 and dpp18E05 FlyLight lines.

The BMP Signaling Gradient Patterns Dorsoventral Tissues in a Temporally Progressive Manner along the Anteroposterior Axis Jennifer A. Tucker, Keith.

Volume 15, Issue 5, Pages (March 2005)

Volume 6, Issue 1, Pages (January 2004)

Zebrafish pea3 and erm are general targets of FGF8 signaling

Guidance Cues at the Drosophila CNS Midline: Identification and Characterization of Two Drosophila Netrin/UNC-6 Homologs Robin Harris, Laura Moore Sabatelli,

Volume 12, Issue 3, Pages (March 2007)

Volume 25, Issue 2, Pages (April 2013)

Norihito Kishimoto, Ying Cao, Alice Park, Zhaoxia Sun

Volume 10, Issue 5, Pages (May 2006)

Volume 44, Issue 3, Pages e5 (February 2018)

Gfi1aa suppresses the endothelial gene expression program in primitive erythroblasts developing from the posterior lateral mesoderm. Gfi1aa suppresses.

BrdU incorporation reveals that the NB7-3 lineage generates three GMCs

Smo deficiency in the renal stroma is dependent on GLI3R.

hb and pdm1, but not cas, are expressed in the NB7-3 lineage.

Transplantation experiments.

Foxi1 and Dlx3b mediate convergent pathways of otic development.

Epidermal aggregation in clint1 mutants and interaction with lgl2.

Morphological defects of hi559 GI tract.

Expression of Wnt3EGFP in the cerebellum of Tg(wnt3:Wnt3EGFP)F3 partially compensates cerebellum growth in MO1-injected Wnt3 morphants. Expression of Wnt3EGFP.

The feelgood mutation affects craniofacial skeletal development.

Cyclopamine treatment blocks Hh signalling in Xenopus.

Mutant phenotypes and expression patterns of Drosophila segmentation genes. Mutant phenotypes andexpression patterns of Drosophila segmentation genes.

Spatial expression pattern of CPC promoter::GUS and GL2 promoter::GUS in different mutant backgrounds. Spatial expression pattern of CPC promoter::GUS.

Fig. 7 Cell fate potential of individual neural crest–derived ectomesenchymal clones. Cell fate potential of individual neural crest–derived ectomesenchymal.

Two domains of KHC act to position the nucleus.

Fig. 2. Non-homogeneous subcellular distribution of Vangl2 along the anteroposterior axis. Non-homogeneous subcellular distribution of Vangl2 along the.

Volume 92, Issue 2, Pages (January 1998)

Prophase nuclear movements in wild-type, rec8 and rec7 mutant cells.

Abnormal adherens junctions between hub cells and GSCs in Lar mutants.

A Cyclin-Dependent Kinase Inhibitor, Dacapo, Is Necessary for Timely Exit from the Cell Cycle during Drosophila Embryogenesis Joriene C de Nooij, Mary.

Cell-autonomous migration of gata5/smarcd3b-expressing cells to the heart. Cell-autonomous migration of gata5/smarcd3b-expressing cells to the heart. (A-E)

The zebrafish swdp75fm and swdp82mf mutations cause exocrine pancreatic hypoplasia and reduced skin pigmentation. The zebrafish swdp75fm and swdp82mf mutations.

Critical role of biklf in erythroid cell differentiation in zebrafish

Fig. 7. Rho family GTPase signaling is required for cyst formation in Ptp4E Ptp10D mutants.(A–C) Expression of DN Rho1 and Rac1 mutants in wild-type (w1118)

Phenotypic analysis of the CNS in mutants for Ror, otk and otk2

Expression of VPAC2 in the pancreas at E13.

Volume 115, Issue 5, Pages (November 2003)

Genetic interaction between e(y)1 and Notch in wing development.

A tph2 promoter fragment labels DR serotonergic neurons.

Postmortem changes of the brain and aneurysm.

ET-1 effect on neuronal viability and blood flow.

Fgfr1a, fgfr1b, and fgfr2 function redundantly to regulate pectoral fin development. fgfr1a, fgfr1b, and fgfr2 function redundantly to regulate pectoral.

Presentation transcript:

Neurocranial cartilage patterns in wild-type and Hh-deficient larvae. Neurocranial cartilage patterns in wild-type and Hh-deficient larvae. Alcian stained cartilages were dissected and flat mounted; dorsal views are shown, anterior to the left. (A) The wild-type ANC at 4.5 dpf includes paired trabeculae (tr) and an ethmoid plate (eth). Mandibular (pq) and hyoid (hs) cartilages remain attached. (B,C) Neurocranial defects in syu mutants. Trabecular cartilages either fuse completely (B) or partially (C, arrowheads) at the midline. (D-F) Concentration-dependent effects of co-injected shh-MO and twhh-MO in wild type: (D) 3.0 ng shh-MO + 0.82 ng twhh-MO; (E) 2.0 ng shh-MO + 0.55 ng twhh-MO; (F) 1.0 ng shh-MO + 0.27 ng twhh-MO. bp, basal plate; eth, ethmoid plate; hf, hypophysial fenestra; hs, hyosymplectic; pq, palatoquadrate; p, polar cartilage; tr, trabeculae. Naoyuki Wada et al. Development 2005;132:3977-3988 © 2005.