Fig. 1. The ZNF804A interactome

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Fig. 1. The ZNF804A interactome Fig. 1. The ZNF804A interactome. Schematic depicting the domain architecture of ZNF804A and its paralog GPATCH8 (A). ... Fig. 1. The ZNF804A interactome. Schematic depicting the domain architecture of ZNF804A and its paralog GPATCH8 (A). Images were produced using SMART and are annotated to show protein domains and motifs. GPATCH8 differs from ZNF804A at its N-terminus where the larger protein contains a G-patch domain and an extensive coiled-coil region (green). GPATCH8 also contains a higher proportion of low complexity protein sequence (pink) than its paralog. The bisecting lines show the location of the coding exon boundaries in the 2 proteins. The position of the Y2H baits (a-d) is shown below each protein. Protein-protein interaction (PPI) network for ZNF804A and GPATCH8 (B). PPI was produced in CYTOSCAPE and shows combined Y2H data from the four baits depicted in panel A. Interacting genes are color-coded according to molecular function; baits, yellow; messenger RNA processing and binding, orange; RNA-associated, purple; transcription, red; ubiquitin-proteasome, green; unspecified, light blue. Gene Ontology (GO) enrichment for the entire ZNF804A interactome (C). Enrichment analysis was performed on the list of interactors using ToppGene. The top 3 statistically significant GO molecular function (red) and GO biological processes (green) are shown after Bonferroni correction. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Schizophr Bull, sby183, https://doi.org/10.1093/schbul/sby183 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 2. Alternative splicing events in ZNF804A-depleted cells Fig. 2. Alternative splicing events in ZNF804A-depleted cells. Geneview for ENAH after ZNF804A knockdown (A). ... Fig. 2. Alternative splicing events in ZNF804A-depleted cells. Geneview for ENAH after ZNF804A knockdown (A). Following ZNF804A knockdown there was increased exclusion of the exon 11a (highlighted with an oval). Screenshot showing the genomic region containing ENAH exon 11a and flanking exons displayed using the UCSC Genome Browser (B). Reverse transcription polymerase chain reaction (RT-PCR) using primers complementary to the constitutive exons flanking ENAH exon 11a (C). Quantitative PCR (qPCR) using primers complementary to exon 11a and a control pair complementary to another region on the transcript (D). The expression of exon 11a was compared between samples using the ∆∆Ct method with the control primer set as the endogenous normalizer. The bar graph shows the percentage abundance of exon 11a relative to the glyceraldehyde-3-phosphate dehydrogenase-specific siRNA (siGAP)-treated sample. The error bars represent the standard deviation of the raw Ct values. The significance was assessed using a 1-way ANOVA and Tukey’s post-hoc test. ** P < .05. PTPRR isoform switch in ZNF804A-depleted cells (D). PTPRR geneview showed a switch in transcript variant use in ZNF804A-depleted cells. qPCR using the primers complementary to each transcript of PTPRR (E). The expression of each PTPRR transcript was compared between samples using the ∆∆Ct method with beta actin (ACTB) set as the endogenous normalizer. The bar graph shows the relative abundance of each PTPRR transcript relative to the abundance of the canonical transcript (NM_130846.2) in the siGAP-treated sample. NM_002849 (canonical membrane bound). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Schizophr Bull, sby183, https://doi.org/10.1093/schbul/sby183 The content of this slide may be subject to copyright: please see the slide notes for details.

Fig. 3. Enrichment analysis of differentially expressed (DEX) and differentially spliced genes in ZNF804A-depleted ... Fig. 3. Enrichment analysis of differentially expressed (DEX) and differentially spliced genes in ZNF804A-depleted cells. The lists of DEX and differentially spliced genes between ZNF804A-specific siRNA-treated and glyceraldehyde-3-phosphate dehydrogenase-specific siRNA-treated samples (FDR 0.01) were imported into GeneGo Metacore. The bar charts show the top ranked Gene Ontology (GO) Processes (A, DEX) and (C, alternative splicing) and GeneGo Process Networks (B, DEX) identified by the enrichment analysis after multiple test correction (FDR 0.05). In all cases, only ontologies that pass multiple test correction are shown. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Schizophr Bull, sby183, https://doi.org/10.1093/schbul/sby183 The content of this slide may be subject to copyright: please see the slide notes for details.