Study of the specific miRNA profile during the window of implantation (WOI). Study of the specific miRNA profile during the window of implantation (WOI).

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Study of the specific miRNA profile during the window of implantation (WOI). Study of the specific miRNA profile during the window of implantation (WOI). (A) Heat map of the differential expression of secreted maternal miRNAs during the WOI relative to other phases of the menstrual cycle. (B) Supervised principal components analysis (PCA) to distinguish differentially expressed miRNAs in endometrial fluid (EF) obtained throughout the menstrual cycle relative to the WOI. (C) Venn diagram demonstrating the overlap in expression of miRNAs at different phases of the menstrual cycle, with special attention on hsa-miR-30d in the WOI. (D) Hsa-miR-30d concentration in the EF throughout the menstrual cycle. Boxes represent the first quartile, median and third quartile, and error bars represent maximum and minimum values. Felipe Vilella et al. Development 2015;142:3210-3221 © 2015. Published by The Company of Biologists Ltd