Conrad Waddington's diagram of the epigenetic landscape.

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Presentation transcript:

Conrad Waddington's diagram of the epigenetic landscape. Conrad Waddington's diagram of the epigenetic landscape. Genes (solid pegs at the bottom) are viewed as parts of complex networks so that many gene products interact between themselves and with the phenotype to produce the phenotypic landscape (top) through which development occurs. Waddington's insight was that new forms could arise through new combinations to produce new landscapes in response to environmental pressure, and that these could then be assimilated into the genome. Waddington was a systems biologist in the full sense of the word. If we had followed his lead many of the more naive 20th century popularisations of genetics and evolutionary biology could have been avoided. Image taken from The Strategy of the Genes (Waddington, 1957). Reprinted (2014) by Routledge Library Editions. Denis Noble J Exp Biol 2015;218:7-13 © 2015. Published by The Company of Biologists Ltd