Development of the SAN. (A) Schematic of key factors expressed in the developing SV and SAN of mouse embryos. Development of the SAN. (A) Schematic of.

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Development of the SAN. (A) Schematic of key factors expressed in the developing SV and SAN of mouse embryos. Development of the SAN. (A) Schematic of key factors expressed in the developing SV and SAN of mouse embryos. (B) Scheme depicting the roles of and the genetic interactions between factors involved in SAN formation. The dashed line indicates indirect activation of the SAN gene programme by Shox2. LA, left atrium; PV, pulmonary vein; RA, right atrium; SAN, sinoatrial node; SV, sinus venosus; WM, working myocardium. Jan Hendrik van Weerd, and Vincent M. Christoffels Development 2016;143:197-210 © 2016. Published by The Company of Biologists Ltd