Manipulation of cGMP levels in the Malpighian tubule by cell-specific transgenic expression of a rat atrial natriuretic peptide (ANP) receptor. Manipulation.

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Manipulation of cGMP levels in the Malpighian tubule by cell-specific transgenic expression of a rat atrial natriuretic peptide (ANP) receptor. Manipulation of cGMP levels in the Malpighian tubule by cell-specific transgenic expression of a rat atrial natriuretic peptide (ANP) receptor. The results refer to flies in which expression of UAS-GC-A was driven ubiquitously by heat-shock GAL4, in tubule principal cells by GAL4 line c42, or in tubule stellate cells by GAL4 line c724. (A) Effects on whole-tubule cGMP. The receptor can drive increases in cGMP in either principal or stellate cells. (B) Fluid secretion. Elevation of cGMP in either principal or stellate cells elicits increased fluid secretion. Asterisks denote significant difference from corresponding control values (Student's t-test, P<0.05). [From Kerr et al. (Kerr et al., 2004).] Julian A. T. Dow J Exp Biol 2009;212:435-445 ©2009 by The Company of Biologists Ltd