Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3- galactose Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Hayley.

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Presentation transcript:

Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3- galactose Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Hayley James, BS, Thomas A.E. Platts-Mills, MD, PhD, FRS, Scott Commins, MD, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 5, Pages 1334-1342.e1 (May 2012) DOI: 10.1016/j.jaci.2012.02.038 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Titration of intradermal gelatin colloid skin testing. Intradermal testing with gelatin colloid was titrated in 17 patients, with positive test results detectable at dilutions of undiluted colloid only (3 patients) and 1:10 (6 patients), 1:100 (8 patients), and 1:1000 (0 patients) dilution. Representative examples are shown. GC, Gelatin colloid; ID, idiopathic; M, meat. Journal of Allergy and Clinical Immunology 2012 129, 1334-1342.e1DOI: (10.1016/j.jaci.2012.02.038) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Patient ID1 gelatin colloid challenge. After the equivalent of 0.1 mL of undiluted gelatin colloid (Haemaccel; approximately 3.5 mg of gelatin), a 5 × 8–cm itchy wheal developed around the cannula site at 10:45 am, with progression over the next 30 minutes. With 31 mL (approximately 1.1 g of gelatin), she had axillary and inguinal urticaria, tachycardia, itchy throat, cough, and bronchospasm, and peak flow deteriorated from 540 to 470 L/min, at which point the challenge was terminated Importantly, the cannula remained patent throughout the procedure. Journal of Allergy and Clinical Immunology 2012 129, 1334-1342.e1DOI: (10.1016/j.jaci.2012.02.038) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Standard curve of iodine 125–labeled α-gal inhibition RIA. The concentrations of α-Gal were measured by using inhibition RIA. A standard curve was created with serial dilutions of the linear trisaccharide Galα1-3Galβ1-4GlcNAc. Counts per minute of iodine 125–labeled α-Gal (y-axis) are compared with the concentration of α-Gal (in micrograms per gram of test substance) on the x-axis. Journal of Allergy and Clinical Immunology 2012 129, 1334-1342.e1DOI: (10.1016/j.jaci.2012.02.038) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions