PD-1 blockade results in increased expression of the chemokine receptor CXCR3. PD-1 blockade results in increased expression of the chemokine receptor.

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PD-1 blockade results in increased expression of the chemokine receptor CXCR3. PD-1 blockade results in increased expression of the chemokine receptor CXCR3. A: Representative flow cytometry histogram plots showing CXCR3 expression on Thy1.1+ BDC2.5 T cells from mice that received 200 μg of isotype control or anti–PD-L1 antibody at days −5, −3, and −1 prior to harvest. Mice were harvested 3 weeks posttransfer. Quantification of A showing geometric mean fluorescence intensity (MFI) of CXCR3 (B), the frequency of BDC2.5 T cells expressing CXCR3 (C), and the absolute number of BDC2.5 T cells expressing CXCR3 (D). Data are representative of three independent experiments with at least three mice per treatment condition per experiment. E: Representative flow cytometry contour plots showing Ki67 and CXCR3 expression with or without anti–PD-L1 administration 7 days posttransfer. Data are representative of four experiments with at least three animals per group. ingLN, inguinal LN; pancLN, pancreatic LN. ns, not significant, P > 0.05. *Significant, P = 0.01–0.05. **Very significant, P = 0.001–0.01. ***Extremely significant, P < 0.001. Kristen E. Pauken et al. Diabetes 2013;62:2859-2869 ©2013 by American Diabetes Association