Yu-Chen Huang, MD, Ying-Chih Cheng, MD

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Presentation transcript:

Isotretinoin treatment for acne and risk of depression: A systematic review and meta- analysis Yu-Chen Huang, MD, Ying-Chih Cheng, MD Journal of the American Academy of Dermatology Volume 76, Issue 6, Pages 1068-1076.e9 (June 2017) DOI: 10.1016/j.jaad.2016.12.028 Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Selection of studies included in the present systematic review and meta-analysis. Journal of the American Academy of Dermatology 2017 76, 1068-1076.e9DOI: (10.1016/j.jaad.2016.12.028) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Forest plot. Standardized mean difference in depression score change from baseline (post-score minus pre-score) between the isotretinoin group and the control group (isotretinoin group minus control group). The more negative a standardized mean difference is the greater the improvement in depression scores in the isotretinoin group in comparison with the control group. Journal of the American Academy of Dermatology 2017 76, 1068-1076.e9DOI: (10.1016/j.jaad.2016.12.028) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Funnel plot analysis for potential publication bias. The funnel plot for change in depression scores in 19 studies showed no asymmetry, which means no publication bias. Each dot represents a study; the y-axis represents the standard error of the study and the x-axis shows the study result (standardized mean difference of pre- and post-treatment depression scores in each study). Journal of the American Academy of Dermatology 2017 76, 1068-1076.e9DOI: (10.1016/j.jaad.2016.12.028) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions