Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P<0.01 by ANOVA and post hoc LSD testing; DD versus.

Slides:

Advertisements

Similar presentations

Mitochondria localize to both the front and the rear of neutrophils.

Advertisements

Structure of abbreviated dystrophins.

Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.

Fig. 3. Effect of NH4Cl (0 or 30 mM) on percentage of motile spermatozoa and VAP after 1 and 5 min after activation. Effect of NH4Cl (0 or 30 mM) on percentage.

Fig. 2. Proportion of motile objects and track length

Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/−

OA and related amines modulate motility and length of schistosomula.

Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Mean.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Crotonate prevents downregulation of kidney PGC-1α and SIRT3 as well as causing CCL2 upregulation in experimental AKI. AKI was induced by a folic acid.

Crotonate increases histone crotonylation in mouse kidney.

Effect of OLHHA on the protein expression of relevant enzymes and factors related to lipid metabolism in the liver of obese Zucker rats. Effect of OLHHA.

Concentration of biomarkers of haemostasis.

Validation of ddPCR assay for detection of KrasLox-G12D allele using LNA-2 primers. Validation of ddPCR assay for detection of KrasLox-G12D allele using.

TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Asj-2J mice show a progressive age-dependent increase in calcification in aorta, muzzle skin containing the dermal sheath of the vibrissae, kidney, spleen.

Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.

Effects of embryonic hypoxia on fasted and postprandial cardiac output

Effects of embryonic hypoxia on fasted and postprandial heart rate and stroke volume. Effects of embryonic hypoxia on fasted and postprandial heart rate.

Working hypothesis of histone lysine crotonylation in kidney injury.

TWEAK downregulates SIRT3 in cultured tubular cells and this is prevented by crotonate. TWEAK downregulates SIRT3 in cultured tubular cells and this is.

Behavioral test parameters.

Obesity affected the metabolic response to stroke.

Expression data confirm and extend existing knowledge

Factors affecting standardization of rodent impact TBI models.

Silencing of Keap1 reduced the expression of inflammatory markers in ConA-injected livers. Silencing of Keap1 reduced the expression of inflammatory markers.

Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W embryos at E16.5. Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W.

Hipk induces overgrowths in Drosophila imaginal discs.

Treatment of HCMT-CMs with bisoprolol.

Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects.

Heatmap of relative expression levels of 75 O

Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections.

Elevated expression of vegfaa in hemangiosarcoma.

Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs. Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs.

The effect of TDP-43A315T expression on dendrite spine development.

The mutants exhibit congenital hypothyroidism.

Distribution and extent of expression.

Intestinal CAV1 deletion alters circulating FFAs but not TGs

The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.

Variations in tissue stiffness.

Characterization of zebrafish muscle wasting in krasG12V-induced HCC zebrafish. 4-month-old male adult krasG12V and WT zebrafish were treated with dox.

Abnormalities that are combined with or are indicators for life-threatening defects (Sc4). Abnormalities that are combined with or are indicators for life-threatening.

TWEAK increases histone crotonylation in kidney tubular cells.

The effect of TDP-43A315T expression at the synapse.

Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.

Increased expression of the drusen-associated genes (ApoE, ApoJ, ApoB and App) and Vegfa in the RPE/retina of Pgc-1α+/− mice under RD and HFD. (A) The.

Impact of low-level galactose exposure on acute and long-term outcomes in GALT-null Drosophila. Impact of low-level galactose exposure on acute and long-term.

Food-additive exposure increases permeability in a human gut cell co-culture model. Food-additive exposure increases permeability in a human gut cell co-culture.

Food-additive exposure reduces adult fly survival under some feeding conditions. Food-additive exposure reduces adult fly survival under some feeding conditions.

Impact of maternal loading for GALK on survival of larvae to adulthood in the presence versus absence of 200 mM dietary galactose. Impact of maternal loading.

Anti-epileptic drugs with Na+ channel blocking activity improve QTc in individuals with Rett syndrome. Anti-epileptic drugs with Na+ channel blocking activity.

HEK-cFXN cells show a correlation among ROS levels, LIP and frataxin expression. HEK-cFXN cells show a correlation among ROS levels, LIP and frataxin expression.

Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Guinea pigs fed HFHC diet develop impaired glucose tolerance.

Cross-validation between centres for inbred mice.

Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina.

Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants.

Cardiac phenotypes in mouse models of systemic lupus erythematosus (SLE). Cardiac phenotypes in mouse models of systemic lupus erythematosus (SLE). We.

The expression of two forms of N-cadherin.

ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)

Fig. 2. Effects of pH on percentage of motile spermatozoa and VAP after 1 and 5 min after activation. Effects of pH on percentage of motile spermatozoa.

Peroxisome speeds were slower in patient and control cells.

The vps13 mutants are hypersensitive to SDS but cell wall integrity is not compromised. The vps13 mutants are hypersensitive to SDS but cell wall integrity.

Summary of variabilities in hiPSC-CMs.

Effect of siRNA transfection on colony formation by Renca cells.

Graphical representation of pain levels versus time postinjury, annotated across control, persistently hypersensitive genotypes and diabetic conditions,

A normal/intermediate activity of calmodulin-calcineurin pathway is required to cope with SDS stress in vps13Δ. A normal/intermediate activity of calmodulin-calcineurin.

Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)

Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus.

Presentation transcript:

Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P<0.01 by ANOVA and post hoc LSD testing; DD versus RD within each strain; data are mean±s.e.m. Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P<0.01 by ANOVA and post hoc LSD testing; DD versus RD within each strain; data are mean±s.e.m. Chana Yagil et al. Dis. Model. Mech. 2018;11:dmm036699 © 2018. Published by The Company of Biologists Ltd