Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects Neil E. Alexis,

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Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects Neil E. Alexis, PhDa, Marlowe W. Eldridge, MDa,b,c,d, David B. Peden, MD, MSa,c Journal of Allergy and Clinical Immunology Volume 112, Issue 2, Pages 353-361 (August 2003) DOI: 10.1067/mai.2003.1651 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Mean (± SEM) phagocytosis of opsonized zymosan particles (MFI) of recovered sputum (airway) macrophages, monocytes, and neutrophils in atopic asthmatic individuals 6 hours after endotoxin (closed bar) and saline (open bar) inhalation challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Mean (± SEM) phagocytosis of opsonized zymosan particles (MFI) of recovered circulating (blood) monocytes and neutrophils in atopic asthmatic individuals 6 hours after endotoxin (closed bar) and saline (open bar) inhalation challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig 3 A, Relationship between degree of neutrophilic inflammation in the airways, expressed as percent change in sputum neutrophils (post-endotoxin–post-saline PMN counts in sputum) and the percent decrease in sputum macrophage phagocytosis (difference between post-endotoxin–post-saline × 100%) after endotoxin challenge in 7 atopic asthmatic individuals. B, Relationship between degree of neutrophilic inflammation in the airways, expressed as percent change in sputum neutrophils (post-endotoxin–post-saline PMN counts in sputum) and the percent decrease in peripheral blood monocyte (PBM) phagocytosis (difference between post-endotoxin–post saline × 100%) after endotoxin challenge in 7 atopic asthmatic individuals. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Relationship between constitutive CD11b expression (MFI) on blood monocytes (A) and neutrophils (B) and the degree of neutrophilic inflammation in the airways 6 hours after endotoxin inhalation challenge in 10 atopic asthmatic individuals. Spearman correlation coefficient: (R) = 0.9, P = .001 (A) ; (R) = 0.7, P = .03 (B) . Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 5 Mean (± SEM) CD11b expression (MFI) on blood monocytes in atopic asthmatic individuals 6 hours after inhaled endotoxin (LPS; closed bar ) and saline (open bar) challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 6 Mean (± SEM) mCD14 expression (MFI) on sputum monocytes, macrophages, and neutrophils in atopic asthmatic individuals 6 hours after inhaled endotoxin (LPS; closed bar ) and saline (open bar) challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions