Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects  Neil E. Alexis,

Slides:



Advertisements
Similar presentations
W.Travis Cain, MDa, Greg Cable, PhDb, John J. Oppenheimer, MDc 
Advertisements

Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy  Monica B. Arvidsson, MD, Olle.
Evaluation and treatment of allergic fungal sinusitis. II
Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison.
The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,
Neil E. Alexis, Marianne S. Muhlebach, David B. Peden, Terry L. Noah 
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma  Patrick Booms, MSca, David.
Evaluation and treatment of allergic fungal sinusitis. II
Hong Wei Chu, MDa, Monica Kraft, MDa, James E. Krause, PhDb, Michael D
Is 9 more than 2 also in allergic airway inflammation?
Practice Notes from the AAAI
Badrul A. Chowdhury, MD, PhD 
Hydroxychloroquine improves airflow and lowers circulating IgE levels in subjects with moderate symptomatic asthma  B.Lauren Charous, MD, Elkan F. Halpern,
Histamine in the immune regulation of allergic inflammation
Chronic sinusitis in severe asthma is related to sputum eosinophilia
Xaver Baur  Journal of Allergy and Clinical Immunology 
Elephantiasis nostras: A case report
Jerome A. Sigua, MD, Becky Buelow, MD, Dorothy S
Conjunctivitis medicamentosa
The glutathione-S-transferase mu 1 (GSTM1) null genotype and increased neutrophil response to low-level ozone (0.06 ppm)  Neil E. Alexis, PhD, John C.
Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways  Anthony J. Frew, MD, Johanne St-Pierre,
John-Paul Oliveria, BSc, Brittany M
Increased sensitivity to bradykinin among African Americans
Evidence for expression of eosinophil-associated IL-12 messenger RNA and immunoreactivity in bronchial asthma  Esra Nutku, MDa, Abdelilah Soussi Gounni,
Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: Effects of single allergen challenge  Adriaan.
Pathophysiology of the inflammatory response
News & Notes Journal of Allergy and Clinical Immunology
Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers  Neil E. Alexis, PhD, John.
Jill A. Poole, MD, Neil E. Alexis, PhD, Conrad Parks, BS, Amy K
Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype  Atsuko Takao, MDa, Terufumi Shimoda, MDa, Shigeru Kohno, MDa, Sadahiro.
Circadian variation of sputum inflammatory cells in mild asthma
Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization  Qutayba Hamid, MD, PhD, Editor  Journal.
Epithelial cells as regulators of airway inflammation
Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and.
Lisa G. Wood, PhD, Manohar L. Garg, PhD, Peter G. Gibson, MBBS 
Airway inflammation in occupational asthma caused by styrene
Patterns of pollen cross-allergenicity
Molecular virology and immunology of HIV infection
Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients  Charles McSharry, PhD,
Exercise-induced bronchoconstriction in children: Montelukast attenuates the immediate-phase and late-phase responses  Raul E. Melo, MD, Dirceu Solé,
David M. Brass, PhD, John W. Hollingsworth, MD, Michael B
Vascular endothelial growth factor in patients with acute asthma
News & Notes Journal of Allergy and Clinical Immunology
Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma  Yasurou Kohno, MDa,
Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy  Olivier Michel,
Antiresorptive therapy in asthmatic patients receiving high-dose inhaled steroids: A prospective study for 18 months  Wei Qing Wang, MB, Mary Sau Man.
Fractional analysis of sequential induced sputum samples during sputum induction: Evidence that different lung compartments are sampled at different time.
Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression  Willie June Brickey, PhD, Neil.
Intracellular IL-5 and T-lymphocyte subsets in atopic and nonatopic bronchial asthma  Yutaro Shiota, MD, PhDa, Hitomi Arikita, MTa, Naokatsu Horita, MDb,
The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects  Neil E. Alexis, PhD, Haibo Zhou, PhD,
Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation  Anthony P. Sampson, PhDa, Emilio Pizzichini, MD, PhDb,
The effects of IL-5 on airway physiology and inflammation in rats
Practice Notes from the AAAI
Allergy and asthma in elite summer sport athletes
Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis  Toyoyuki Hanazawa, MD, PhD, Julio.
Changes in sputum counts and airway hyperresponsiveness after budesonide: Monitoring anti-inflammatory response on the basis of surrogate markers of airway.
Determinants of systemic manifestations of food allergy
Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma  Sun Ying,
Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma  Sally E. Wenzel, MD  Journal of Allergy and Clinical.
Effect of continuing or finishing high-level sports on airway inflammation, bronchial hyperresponsiveness, and asthma: A 5-year prospective follow-up.
Neil E. Alexis, PhD, John C. Lay, PhD, Martha Almond, RRT, David B
Reply Journal of Allergy and Clinical Immunology
Footnotes1 Journal of Allergy and Clinical Immunology
Prescott G. Woodruff, MD, MPH, Ramin Khashayar, MD, Stephen C
Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic.
Expression of prostaglandin E2 receptor subtypes on cells in sputum from patients with asthma and controls: Effect of allergen inhalational challenge 
News & Notes Journal of Allergy and Clinical Immunology
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Pascal Chanez, MDa, Antonio M
Presentation transcript:

Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects  Neil E. Alexis, PhDa, Marlowe W. Eldridge, MDa,b,c,d, David B. Peden, MD, MSa,c  Journal of Allergy and Clinical Immunology  Volume 112, Issue 2, Pages 353-361 (August 2003) DOI: 10.1067/mai.2003.1651 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Mean (± SEM) phagocytosis of opsonized zymosan particles (MFI) of recovered sputum (airway) macrophages, monocytes, and neutrophils in atopic asthmatic individuals 6 hours after endotoxin (closed bar) and saline (open bar) inhalation challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Mean (± SEM) phagocytosis of opsonized zymosan particles (MFI) of recovered circulating (blood) monocytes and neutrophils in atopic asthmatic individuals 6 hours after endotoxin (closed bar) and saline (open bar) inhalation challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig 3 A, Relationship between degree of neutrophilic inflammation in the airways, expressed as percent change in sputum neutrophils (post-endotoxin–post-saline PMN counts in sputum) and the percent decrease in sputum macrophage phagocytosis (difference between post-endotoxin–post-saline × 100%) after endotoxin challenge in 7 atopic asthmatic individuals. B, Relationship between degree of neutrophilic inflammation in the airways, expressed as percent change in sputum neutrophils (post-endotoxin–post-saline PMN counts in sputum) and the percent decrease in peripheral blood monocyte (PBM) phagocytosis (difference between post-endotoxin–post saline × 100%) after endotoxin challenge in 7 atopic asthmatic individuals. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Relationship between constitutive CD11b expression (MFI) on blood monocytes (A) and neutrophils (B) and the degree of neutrophilic inflammation in the airways 6 hours after endotoxin inhalation challenge in 10 atopic asthmatic individuals. Spearman correlation coefficient: (R) = 0.9, P = .001 (A) ; (R) = 0.7, P = .03 (B) . Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 5 Mean (± SEM) CD11b expression (MFI) on blood monocytes in atopic asthmatic individuals 6 hours after inhaled endotoxin (LPS; closed bar ) and saline (open bar) challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 6 Mean (± SEM) mCD14 expression (MFI) on sputum monocytes, macrophages, and neutrophils in atopic asthmatic individuals 6 hours after inhaled endotoxin (LPS; closed bar ) and saline (open bar) challenge. Journal of Allergy and Clinical Immunology 2003 112, 353-361DOI: (10.1067/mai.2003.1651) Copyright © 2003 Mosby, Inc. Terms and Conditions