Compliance with each Landis criteria for in vivo experiments for NPG (top two panels of each quartet) and non-NPG articles (lower two panels) before and.

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Compliance with each Landis criteria for in vivo experiments for NPG (top two panels of each quartet) and non-NPG articles (lower two panels) before and after 1 May 2013. Compliance with each Landis criteria for in vivo experiments for NPG (top two panels of each quartet) and non-NPG articles (lower two panels) before and after 1 May 2013. (A) Randomisation; (B) blinding; (C) sample size calculation; and (D) reporting of exclusions. For A–C, black represents studies where compliance was achieved by reporting that the measure was taken; green that compliance was achieved by describing that the measure was not taken; and white that compliance was not achieved. For D, black represents studies where exclusions were reported and white that exclusions were not reported. NPG, Nature Publishing Group. The NPQIP Collaborative group BMJ Open Science 2019;3:e000035 © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.