Kristen Foering, MD, Aileen Y. Chang, MD, Evan W

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Presentation transcript:

Characterization of clinical photosensitivity in cutaneous lupus erythematosus Kristen Foering, MD, Aileen Y. Chang, MD, Evan W. Piette, MD, Andrew Cucchiara, PhD, Joyce Okawa, RN, Victoria P. Werth, MD Journal of the American Academy of Dermatology Volume 69, Issue 2, Pages 205-213 (August 2013) DOI: 10.1016/j.jaad.2013.03.015 Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Photosensitivity survey. Directions: Please circle the answer that best captures the patient's symptoms or write in an answer in the fill-in line. To indicate past or current symptoms, please place “P” for past or “C” for current in the box. Journal of the American Academy of Dermatology 2013 69, 205-213DOI: (10.1016/j.jaad.2013.03.015) Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Cutaneous lupus erythematosus (CLE). Percentage of subjects with photosensitivity (PS) (N = 83) reporting each PS phenotype as captured by PS survey. Because 23 subjects reported both genSkin and general pruritus/paresthesias (genRxn) concomitantly, this overlap is listed on graph to allow for accurate percentage calculation. directCLE, Direct sun-induced CLE flare; genCLE, general exacerbation of CLE; genSys, sun-induced systemic symptoms. Journal of the American Academy of Dermatology 2013 69, 205-213DOI: (10.1016/j.jaad.2013.03.015) Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Cutaneous lupus erythematosus (CLE). Percentage of time courses for photosensitivity (PS) reactions among subjects experiencing direct sun-induced CLE flare (directCLE), genSkin, and general pruritus/paresthesias (genRxn). Early, PS symptoms occur within minutes to next day; lasting, PS symptoms last for weeks to months; transient, PS symptoms resolve same day to within 1 week; late, PS symptoms occurring from 1 day to 1 week after sun exposure. Journal of the American Academy of Dermatology 2013 69, 205-213DOI: (10.1016/j.jaad.2013.03.015) Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Cutaneous lupus erythematosus (LE). Median (± interquartile range) of cell counts for myeloid dendritic cells (CD11c+) and T cells (CD3+) in dermis of patients with LE who are photosensitive with and without sun-induced systemic symptoms (genSys) and in age- and skin type–matched control subjects. Mann-Whitney tests of cell counts of subjects with versus without genSys; ∗P = .04, #P = .06. hpf, High-power field. Journal of the American Academy of Dermatology 2013 69, 205-213DOI: (10.1016/j.jaad.2013.03.015) Copyright © 2013 American Academy of Dermatology, Inc. Terms and Conditions