Cristin C Slater, M. D. , Irene Souter, M. D. , Chunying Zhang, M. D

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Presentation transcript:

Pharmacokinetics of testosterone after percutaneous gel or buccal administration Cristin C Slater, M.D., Irene Souter, M.D., Chunying Zhang, M.D., Chaxiang Guan, M.D., Frank Z Stanczyk, Ph.D., Daniel R Mishell, M.D. Fertility and Sterility Volume 76, Issue 1, Pages 32-37 (July 2001) DOI: 10.1016/S0015-0282(01)01827-1

Figure 1 Mean serum total testosterone (T) levels on treatment days (D) 1 and 14. Subjects used one application daily of either 1 mg of micronized testosterone transdermal gel or 1 mg of testosterone propionate buccal lozenge. Blood samples were studied at hours 0 (before administration of testosterone), 1, 2, 3, 4, 6, 8, 12, 18, and 24. Diamond = lozenge D-1; square = gel D-1; triangle = lozenge D-14, X = gel D-14. Slater. Postmenopausal testosterone replacement. Fertil Steril 2001. Fertility and Sterility 2001 76, 32-37DOI: (10.1016/S0015-0282(01)01827-1)

Figure 2 Mean serum free testosterone (T) levels on treatment days (D) 1 and 14. Subjects used one application daily of either 1 mg of micronized testosterone transdermal gel or 1 mg of testosterone propionate buccal lozenge. Blood samples were studied at hours 0 (before administration of testosterone), 1, 2, 3, 4, 6, 8, 12, 18, and 24. Diamond = lozenge D-1; square = gel D-1; triangle = lozenge D-14; X = gel D-14. Slater. Postmenopausal testosterone replacement. Fertil Steril 2001. Fertility and Sterility 2001 76, 32-37DOI: (10.1016/S0015-0282(01)01827-1)

Figure 3 Mean serum dihydrotestosterone levels on treatment days (D) 1 and 14. Subjects used one application daily of either 1 mg of micronized testosterone transdermal gel or 1 mg of testosterone propionate buccal lozenge. Blood samples were studied at hours 0 (before administration of testosterone), 1, 2, 3, 4, 6, 8, 12, 18, and 24. Diamond = lozenge D-1; square = gel D-1; triangle = lozenge D-14; X = gel D-14. Slater. Postmenopausal testosterone replacement. Fertil Steril 2001. Fertility and Sterility 2001 76, 32-37DOI: (10.1016/S0015-0282(01)01827-1)