Finding the Optimal Tradeoffs Shibin Mathew, Amy E. Thurber, Suzanne Gaudet  Cell Systems  Volume 4, Issue 2, Pages 149-151 (February 2017) DOI: 10.1016/j.cels.2017.02.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 A Search for Optimal FCD Network Motifs (A) Diagram showing possible connections within a three-node motif, including positive (blue) and negative (red) regulation of activity (solid) or synthesis or degradation (dashed). (B) Diagrams of the topology of two FCD network motifs, an incoherent type 1 feedforward loop (I1-FFL) and a non-linear integral feedback loop (NLIFL). (C) Schematic of the time course of response (quantified by motif output) for two FCD network motifs. All FCD motifs show adaptation with a return to baseline in the steady state (dark orange region), but they differ in the transient regime (light-orange region). Here, we illustrate how transient response can differ in speed (defined as 1/τ, the time to center of mass of the response curve [dot]) and amplitude. (D) Schematic of a Pareto front showing optimal tradeoffs between two tasks. Motifs lying on the front (I1-FFL and motif 2) have reached an optimal tradeoff between task 1 and 2, while any internal motif is suboptimal, with room for improvement in both tasks. Cell Systems 2017 4, 149-151DOI: (10.1016/j.cels.2017.02.002) Copyright © 2017 Elsevier Inc. Terms and Conditions