Assessment of airflow limitation, airway inflammation, and symptoms during virus- induced wheezing episodes in 4- to 6-year-old children George N. Konstantinou,

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Presentation transcript:

Assessment of airflow limitation, airway inflammation, and symptoms during virus- induced wheezing episodes in 4- to 6-year-old children George N. Konstantinou, MD, PhD, MSc, Paraskevi Xepapadaki, MD, PhD, Emmanuel Manousakis, MD, Heidi Makrinioti, MD, Kalliopi Kouloufakou-Gratsia, MD, Photini Saxoni-Papageorgiou, MD, PhD, Nikolaos G. Papadopoulos, MD, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 1, Pages 87-93.e5 (January 2013) DOI: 10.1016/j.jaci.2012.10.033 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Feno changes from baseline levels at the beginning of a wheezing episode (day 0) and 10 (day 10) and 30 (day 30) days after. ns, Nonsignificant. *P < .001, Wilcoxon matched-pairs rank sum test. Lines and error bars correspond to medians and IQRs. Journal of Allergy and Clinical Immunology 2013 131, 87-93.e5DOI: (10.1016/j.jaci.2012.10.033) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Prebronchodilation FEV0.5 changes from baseline levels at the beginning of a wheezing episode (day 0) and 10 (day 30) and 30 (day 30) days after. ns, Nonsignificant. *P < .001, Wilcoxon matched-pairs rank sum test. Lines and error bars correspond to medians and IQRs. Journal of Allergy and Clinical Immunology 2013 131, 87-93.e5DOI: (10.1016/j.jaci.2012.10.033) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Longitudinal associations (for numeric details, see Tables III and IV) between Feno and prebronchodilation FEV0.5 values presented graphically from the beginning until 30 days after an acute wheezing episode. The different colors correspond to different Feno values and have been used to better distinguish the 3-dimensional surface plot. Journal of Allergy and Clinical Immunology 2013 131, 87-93.e5DOI: (10.1016/j.jaci.2012.10.033) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Scatter plot of Feno and FEV0.5 values A, Beginning of the wheezing episode (day 0). B, Ten days after (day 10). C, Thirty days after (day 30). Journal of Allergy and Clinical Immunology 2013 131, 87-93.e5DOI: (10.1016/j.jaci.2012.10.033) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions