Fig. 5 Suppression of lymphangiogenesis in C57BL/6J mice by sVEGFR3-FC or sLYVE-1-FC attenuated CCR7+cell expansion in the kidney, RDLNs, and spleen and.

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Fig. 5 Suppression of lymphangiogenesis in C57BL/6J mice by sVEGFR3-FC or sLYVE-1-FC attenuated CCR7+cell expansion in the kidney, RDLNs, and spleen and ameliorated intrarenal inflammation and fibrosis. Suppression of lymphangiogenesis in C57BL/6J mice by sVEGFR3-FC or sLYVE-1-FC attenuated CCR7+cell expansion in the kidney, RDLNs, and spleen and ameliorated intrarenal inflammation and fibrosis. (A) Schematic showing intervention in UUO mice with the extracellular domain of VEGFR3 [sVEGFR3-FC (sR3)], LYVE-1 [sLYVE-1-FC (sLY)], or sFC (control). WT, wild-type; iv, intravenously. (B and D) LYVE-1 staining of intrarenal and RDLN LVs after sVEGFR3-FC or sLYVE-1-FC treatment of UUO mice (day 7 after surgery). (C) PAS staining of kidney section and kidney weight after sVEGFR3-FC or sLYVE-1-FC treatment of UUO mice (day 7 after surgery). (E to G) Representative RDLN or spleen and weight of RDLN or spleen after sVEGFR3-FC or sLYVE-1-FC treatment of UUO mice (day 7 after surgery). Numbers of CD11c+ DCs, CD4+ T cells, and CD8+ T cells and percentage of CCR7+ T cells in the RDLN, spleen, and kidney in sVEGFR3-FC– or sLYVE-1-FC–treated mice determined by flow cytometry. (H) qPCR analysis of profibrogenic cytokines in UUO mice (day 7 after surgery). (I) Sirius red staining to analyze interstitial fibrosis in UUO mice (day 7 after surgery). Area of positive staining (40×) was determined in HPF. (J) Fibronectin staining to analyze interstitial fibrosis in UUO mice (day 7 after surgery). Area of positive staining (40×) was determined in HPF. (K) Total kidney collagen levels (adjusted for tissue weight) determined by hydroxyproline assay in UUO mice (day 7 after surgery). n = 5 mice per group. Statistical analysis was performed using the Mann-Whitney U test. n.s. > 0.05, *P < 0.05, **P < 0.01. Values are mean ± SEM. Guangchang Pei et al. Sci Adv 2019;5:eaaw5075 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).