Postmitotic Prox1-deficient DG cells exhibit pyramidal cell morphology

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Postmitotic Prox1-deficient DG cells exhibit pyramidal cell morphology. Postmitotic Prox1-deficient DG cells exhibit pyramidal cell morphology. (A,B) Golgi staining reveals the cellular morphology of the neurons from the heterozygous controls (A) and homozygous mutants (B) at P28, after the induction of the Prox1 knockout shown in Fig. 1D. Highly magnified images show parts of the CA3 and the DG regions. The arrows indicate cells with pyramidal morphology; the arrowheads indicate cells with granule morphology (see also Fig. 1H). (C) The proportion of the granule-type and pyramidal-type cells stained with Golgi’s impregnation in the DG of Prox1F/+; CaMK-CreERT2 and Prox1F/F; CaMK-CreERT2 mice. Data are mean±s.d. (n=3 mice). (D) The experimental scheme for the in utero electroporation and Prox1 knockout using CaMK-CreERT2. (E,F) Math2-immunostained DG granule cell layers in the electroporated hippocampus of the heterozygous (E) and homozygous (F) mice. The individual fluorescent staining of the electroporated cells is presented separately on the right (e1, f1 and f2). The cell in f2 might be a remaining granule cell (see also Fig. 1I). The dotted circles outline the cell body. Scale bars: 50 μm. Tomohiko Iwano et al. Development 2012;139:3051-3062 © 2012.