Protection by budesonide and fluticasone on allergen-induced airway responses after discontinuation of therapy Padmaja Subbarao, MD, MSc, Sandra C. Dorman,

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Protection by budesonide and fluticasone on allergen-induced airway responses after discontinuation of therapy Padmaja Subbarao, MD, MSc, Sandra C. Dorman, PhD, Tracey Rerecich, CMLT, Richard M. Watson, BSc, Gail M. Gauvreau, PhD, Paul M. O'Byrne, MB Journal of Allergy and Clinical Immunology Volume 115, Issue 4, Pages 745-750 (April 2005) DOI: 10.1016/j.jaci.2004.11.023 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 The maximal allergen-induced EAR (mean ± SEM) was significantly attenuated by fluticasone but not by budesonide when compared with placebo. No difference in attenuation was detectable between budesonide and placebo. The maximal allergen-induced LAR (mean ± SEM) was significantly attenuated by both fluticasone and budesonide when compared with placebo. No difference in attenuation was detectable between fluticasone and budesonide. Journal of Allergy and Clinical Immunology 2005 115, 745-750DOI: (10.1016/j.jaci.2004.11.023) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Airway responsiveness (MCh PC20 expressed as geometric mean ± geometric SEM) for before treatment (BL), 7 days after treatment (pre allergen), and 24 hours after allergen inhalation (post allergen). Airway responsiveness improved from baseline to before allergen with inhaled steroid but not placebo treatment. However, the airway responsiveness significantly worsened in all groups, despite treatment after allergen challenge. Journal of Allergy and Clinical Immunology 2005 115, 745-750DOI: (10.1016/j.jaci.2004.11.023) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Changes in sputum eosinophils (mean percentage ± SEM) between 7 days after treatment (pre allergen) and 24 hours after allergen inhalation (post allergen). The allergen-induced increase in the number of sputum eosinophils was significantly decreased with fluticasone and budesonide treatment compared with placebo treatment. Journal of Allergy and Clinical Immunology 2005 115, 745-750DOI: (10.1016/j.jaci.2004.11.023) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions