Isoforms and domain structures of mammalian and invertebrate spectraplakins. Isoforms and domain structures of mammalian and invertebrate spectraplakins.

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Isoforms and domain structures of mammalian and invertebrate spectraplakins. Isoforms and domain structures of mammalian and invertebrate spectraplakins. (A) Major isoforms of the spectraplakin proteins MACF1, BPAG1, Shot, VAB-10 and MACF1a are classified according to their domain structure similarity. Many functional domains can be identified in spectraplakin family proteins, including: calponin homology (CH) domains for F-actin binding, a plakin domain, an α-helical spectrin repeat domain, a PRD, plectin repeats, tandem EF-hand motifs (the distal and proximal motif to the GAR domain are differentially colored), and a GAS2-related (GAR) domain for MT interaction. The number of spectrin repeats and plectin repeats are descriptive in nature and may vary in different spectraplakins. The figure is not drawn to scale with respect to the actual spectraplakin proteins. This panel has been adapted from Suozzi et al. (2012) with permission. (B) The similarity of the spectraplakin members. The homology tree was generated using MAFFT version 5 with annotated sequences of spectraplakin proteins retrieved from NCBI genebank database (accession numbers given in parenthesis) (Katoh et al., 2005). Jamie Zhang et al. J Cell Sci 2017;130:2447-2457 © 2017. Published by The Company of Biologists Ltd