NEXGEN Four All automated microplate processors today can perform the steps required to process an ELISA microplate test However, most systems today operate specifically to their reagent menu and lack the capability to perform as a true open system We allow you to choose your reagent systems Competitive systems claim 4-plate capability However, NO other system today can truly fulfill the claim of utilizing all 4 plates simultaneously, providing you faster turnaround of results

NEXGEN Four Gives You Effective laboratory integration High volume throughput of results Reliability User choice of operation Simple user interface Comprehensive data reduction Future laboratory requirements

NEXGEN Four Effective Laboratory Operation Integration Prevent costly sample pour-off Various tube sizes / types within same rack

NEXGEN Four Effective Laboratory Operation Integration Prevent costly sample pour-off Various tube sizes / types within same rack Reduce barcode read failures Accommodate various barcode systems High percentage read rate Positive internal ID and external scanners Easy interface format ASTM Bi-directional Fully open reagent platform Accommodate existing manufacturers tests Eliminate lengthy correlations

NEXGEN Four High Volume Throughput of Single or Multiple Tests Independent dual robotic arms Simultaneous pipetting of multiple plates

NEXGEN Four High Volume Throughput of Single or Multiple Tests Independent dual robotic arms Simultaneous pipetting of multiple plates Independent dual washheads Without utilizing robotic arm No plate transport systems Simultaneous pipetting and washing

NEXGEN Four High Volume Throughput of Single or Multiple Tests Continuous loading of samples Easy to load individual sample sectors No waiting until existing run is complete Ability to add tests as runs finish

NEXGEN Four High Volume Throughput of Single or Multiple Tests Continuous loading of samples Easy to load individual sample sectors No waiting until existing run is complete Ability to add tests as runs finish Minimized timing conflicts of processing steps Run more assays at one time Process more samples of the same assay

NEXGEN Four High Volume Throughput of Single or Multiple Tests Ability to run infectious and non-infectious tests simultaneously Ability to pipette both metal needle and plastic tips at the same time

NEXGEN Four High Volume Throughput of Single or Multiple Tests Ability to run infectious and non-infectious tests simultaneously Ability to pipette both metal needle and plastic tips at the same time Intelligent sample / assay scheduling Automatic mode for sampling optimization Operator defined mode

NEXGEN Four Reliability Proven design features supported by 15 years experience Only four moveable components Pipetting arm Plate carrier Washhead Carousel Minimal linear plate movement

NEXGEN Four Reliability Proven design features supported by 15 years experience Only four moveable components Pipetting arm Plate carrier Washhead Carousel Minimal linear plate movement Reduced component travel distance

Simplified User Interface Everything comes to you Front-end loading

Simplified User Interface Everything comes to you Front-end loading Touch screen Minimal start up/ shut down time Minimal maintenance

User Choice of Operation Quick and easy graphic selections for the experienced operator Set up check lists mode for infrequent user operation

NEXGEN Four Comprehensive Data Reduction Capabilities Multiple results on one sample including interpretative, qualitative and quantitative Kinetic reading options Automatic run validation checks Unlimited QC parameter definitions

NEXGEN Four Future Laboratory Requirements Multiple workstation access through laboratory network Internet connectivity Troubleshooting Programming Software upgrades Updated product information Remote dialup options

NEXGEN Four Technologies Under Development Allergy testing Tentative release – July, 2003 Immunofluorescent slide processing Tentative release – January, 2004 Agglutination automation

NEXGEN Four Automated platform with a capacity of 4 microplates - 16 tests simultaneously – up to 240 specimens with continuous loading – touch screen – ability to expand to IFA slide prep and agglutination assays for allergy

NEXGEN Four Truly the only open, fully supported system that utilizes all 4 plates simultaneously

NEXGEN Four Tips Loader Samples Carousel Reagents

NEXGEN Four Samples loading capacity = 240 (120 and predilutes) Tips loading capacity = 200 + 200 Reagents containers = 44 + 44 positions Washing tanks = 3 + 3 High throughput = 360 determinations per session Filters reading range = 400 to 700 nm(n.8 filters) Reading range = 0 :3 AU

NEXGEN Four Continuous Sample Loading

NEXGEN Four Sample predilutions: single/serial Positive samples ID: Internal barcode reader with bi-directional interface Positive reagents ID: optional Extractible reagents and samples racks Liquid sensor level for samples, reagents, and buffers Clot detector system for both needles Bubble detection Volumes checking system for plastic tips application

NEXGEN Four 34 Standards and Controls 11 Reagents

NEXGEN Four Two Independent Washheads Separate from Pipettors

NEXGEN Four Fixed metal needle or disposable Plastic Tip to dispense samples Reagent dispensing by Plastic tip for performance and reagent cost

Software Main Features: Real multitasking application Multi-user and multi-instruments accessing by LAN interfacing ASTM communication for LIS/DMS Windows XP Operating System Touch screen and LAN interface Autoimmune and allergy application Remote control Web interface for service

NEXGEN Four

Any Test. Any Combination. Any Time. NEXGEN Four is a trademark of Adaltis