Discrimination of site-specific alterations in gastrointestinal permeability in the rat  Jon B. Meddings, Ian Gibbons  Gastroenterology  Volume 114, Issue 1, Pages 83-92 (January 1998) DOI: 10.1016/S0016-5085(98)70636-5 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Aspirin-induced damage. Data are reported as the mean ± SEM determined from at least 10 animals. (A) Fractional excretion of sucrose. (B) Lactulose-mannitol ratio. (C) Fractional excretion of sucralose. 2, Control animals; ▩, low-dose aspirin; ■, high-dose aspirin. Fractional excretion rates of sucrose are increased with either dose of aspirin and the lactulose-mannitol ratio by high-dose aspirin. Sucralose excretion rates were unaffected by aspirin. *P < 0.05 vs. controls. Gastroenterology 1998 114, 83-92DOI: (10.1016/S0016-5085(98)70636-5) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Indomethacin-induced damage. The format for this figure is identical to that of Figure 1. Indomethacin (Indo) significantly increased both sucrose permeability and the lactulose-mannitol ratio. High-dose indomethacin also significantly increased the fractional excretion of sucralose. *P < 0.05 vs. controls. **P < 0.05 high-dose indomethacin vs. low-dose indomethacin and controls. Gastroenterology 1998 114, 83-92DOI: (10.1016/S0016-5085(98)70636-5) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 3 TNBS colitis. The format for this figure is identical to that of Figure 1. The only probe significantly affected by the presence of colitis was sucralose. *P < 0.05 vs. controls. Gastroenterology 1998 114, 83-92DOI: (10.1016/S0016-5085(98)70636-5) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 4 Sucrose-lactulose ratios. Sucrose-lactulose ratios for all experimental groups are presented. The significance of this measurement is discussed more completely in the text. Indo, indomethacin. *P < 0.05 vs. controls. Gastroenterology 1998 114, 83-92DOI: (10.1016/S0016-5085(98)70636-5) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 5 Lactulose-sucralose ratios. Lactulose-sucralose ratios for all experimental groups are presented. The significance of these data is discussed more extensively in the text. Indo, indomethacin. *P < 0.05 vs. controls. Gastroenterology 1998 114, 83-92DOI: (10.1016/S0016-5085(98)70636-5) Copyright © 1998 American Gastroenterological Association Terms and Conditions