Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma Anne M. Fitzpatrick, PhD, Lou.

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Presentation transcript:

Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma Anne M. Fitzpatrick, PhD, Lou Ann S. Brown, PhD, Fernando Holguin, MD, W. Gerald Teague, MD Journal of Allergy and Clinical Immunology Volume 124, Issue 5, Pages 990-996.e9 (November 2009) DOI: 10.1016/j.jaci.2009.08.039 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Diagram of NO metabolite formation in the airways. Journal of Allergy and Clinical Immunology 2009 124, 990-996.e9DOI: (10.1016/j.jaci.2009.08.039) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Total nitrite plus nitrate (A), nitrite (B), nitrate (C), and nitrotyrosine (D) concentrations (in micromoles per liter) in the proximal (black bars) and distal (gray bars) airway ELF. Data represent means ± SEMs with adult control subjects (AC), pediatric control subjects (PC), subjects with mild-to-moderate asthma (MA), and subjects with severe asthma (SA). aP < .05 versus adult control subjects. bP < .05 versus pediatric control subjects. Journal of Allergy and Clinical Immunology 2009 124, 990-996.e9DOI: (10.1016/j.jaci.2009.08.039) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Scatterplot depicting the relationship between total nitrite plus nitrate and nitrotyrosine concentrations (in micromoles per liter) in the proximal (black circles) and distal (gray circles) airway ELF. Data were logarithmically transformed. Journal of Allergy and Clinical Immunology 2009 124, 990-996.e9DOI: (10.1016/j.jaci.2009.08.039) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Total nitrite plus nitrate (A), nitrite (B), nitrate (C), and nitrotyrosine (D) concentrations (in micromoles per liter) in the proximal (black bars) and distal (gray bars) in the raw BAL supernatant. Data were not adjusted for the urea dilution. Data represent means ± SEMs with adult control subjects (AC), pediatric control subjects (PC), subjects with mild-to-moderate asthma (MA), and subjects with severe asthma (SA). aP < .05 versus adult control subjects. bP < .05 versus pediatric control subjects. Journal of Allergy and Clinical Immunology 2009 124, 990-996.e9DOI: (10.1016/j.jaci.2009.08.039) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions