Prenatal exposure to a farm environment modifies atopic sensitization at birth Markus Johannes Ege, MD, Ileana Herzum, MD, Gisela Büchele, MPH, Susanne.

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Presentation transcript:

Prenatal exposure to a farm environment modifies atopic sensitization at birth Markus Johannes Ege, MD, Ileana Herzum, MD, Gisela Büchele, MPH, Susanne Krauss-Etschmann, MD, Roger P. Lauener, MD, Marjut Roponen, PhD, Anne Hyvärinen, PhD, Dominique A. Vuitton, MD, Josef Riedler, MD, Bert Brunekreef, PhD, Jean-Charles Dalphin, MD, PhD, Charlotte Braun-Fahrländer, MD, Juha Pekkanen, MD, Harald Renz, MD, Erika von Mutius, MD Journal of Allergy and Clinical Immunology Volume 122, Issue 2, Pages 407-412.e4 (August 2008) DOI: 10.1016/j.jaci.2008.06.011 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Recruitment of the study population. Journal of Allergy and Clinical Immunology 2008 122, 407-412.e4DOI: (10.1016/j.jaci.2008.06.011) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Prevalences of detectable IgE for specific allergens in cord blood of farm and reference children. Farm children are represented by black bars, and reference children are represented by gray bars. Statistically significant differences are indicated as follows: ∗P < .05, ∗∗P < .001. D. ptero, D pteronyssinus. Journal of Allergy and Clinical Immunology 2008 122, 407-412.e4DOI: (10.1016/j.jaci.2008.06.011) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 The combined effect of the mother spending any time in animal sheds and handling hay during pregnancy on cord blood–specific IgE levels against grass pollen. Prevalence of sensitization to grass pollen in cord blood is given for the 3 exposure categories. The fourth category (hay contact without exposure to animal sheds) contained only 14 nonsensitized children (<2% of all) and was therefore not included in the figure. Journal of Allergy and Clinical Immunology 2008 122, 407-412.e4DOI: (10.1016/j.jaci.2008.06.011) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Center-adjusted odds ratios for the effects of maternal farm activities on IgE levels for seasonal allergens in cord blood. The odds ratios are adjusted for study center. Only children whose mothers were exposed to animal sheds during pregnancy are included (n = 464). Journal of Allergy and Clinical Immunology 2008 122, 407-412.e4DOI: (10.1016/j.jaci.2008.06.011) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions