An Important Role of Lymphatic Vessels in the Control of UVB-Induced Edema Formation and Inflammation Kentaro Kajiya, Michael Detmar Journal of Investigative.

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Presentation transcript:

An Important Role of Lymphatic Vessels in the Control of UVB-Induced Edema Formation and Inflammation Kentaro Kajiya, Michael Detmar Journal of Investigative Dermatology Volume 126, Issue 4, Pages 920-922 (April 2006) DOI: 10.1038/sj.jid.5700126 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Systemic inhibition of VEGFR-3 prolongs UVB-induced edema formation and inflammation. VEGF transgenic mice were exposed to a single dose of 200mJ/cm2 of UVB irradiation. (a) Ear swelling is expressed as the increase (Δ) in thickness (in μm) over pre-irradiation values. Whereas no differences between anti-VEGFR-3-treated (▪) and control-IgG-treated (♦) mice were observed during the first 4 days after irradiation, the ear thickness of the control-treated mice went back to normal levels after day 6, but anti-VEGFR-3-treated mice showed prolonged ear swelling until day 9 (*P<0.05 at days 6 and 9; **P<0.01 at days 7 and 8). Data are expressed as mean±SE (n=5). (b and c) Hematoxylin–eosin stains at day 9 revealed that the ear skin of (c) anti-VEGFR-3-treated mice retained characteristics of acute photodamage, including epidermal hyperplasia, marked dermal edema, vessel dilation, and inflammatory cell infiltration in the dermis, whereas the findings in (b) control-IgG-treated mice were similar to non-UVB-irradiated mice. (d and e) Immunohistochemistry for CD11b (red) revealed increased macrophage infiltration in the dermis of (e) VFGFR-3-treated mice as compared to mice treated with (d) control-IgG. (b–e) Bars=100μm. Journal of Investigative Dermatology 2006 126, 920-922DOI: (10.1038/sj.jid.5700126) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Prolonged enlargement of lymphatic vessels in anti-VEGFR-3-treated mice. (a and b) Differential immunofluorescence stains for LYVE-1 (red) and CD31 (green) revealed that LYVE-1-positive lymphatic vessels were still enlarged in the ears of (b) VEGFR-3-treated mice at day 9 after UVB irradiation, but not in (a) control-IgG-treated mice. CD31-positive/LYVE-1-negative blood vessels were comparable in both groups. Bars=100μm. (c–e) Morphometric analyses at day 9 after UVB irradiation showed that the area covered by lymphatic vessels (c; *P<0.05) and the average size of lymphatic vessels (d; ***P<0.001) were significantly larger in the ears of anti-VEGFR-3 antibody-treated mice than in mice treated with control-IgG. (e) No significant differences of the number of lymphatic vessels were found between the two groups. Journal of Investigative Dermatology 2006 126, 920-922DOI: (10.1038/sj.jid.5700126) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions