Fibrosis in Fontan physiology

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Presentation transcript:

Fibrosis in Fontan physiology R. Erik Edens, MD, PhD, Peter J. Gruber, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 151, Issue 6, Pages 1527-1528 (June 2016) DOI: 10.1016/j.jtcvs.2016.02.002 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Structure of collagen. Procollagen is composed of 2 α1 chains and 1 α2 chain intertwined into a triple helix. Propeptide domains at the carboxy-terminal and amino-terminal ends are cleaved and released into the plasma. (From Fan D, Takawale A, Lee J, Kassiri Z. Cardiac fibroblasts, fibrosis, and extracellular matrix remodeling in heart disease. Fibrogenesis Tissue Repair. 2012;5:15.) The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1527-1528DOI: (10.1016/j.jtcvs.2016.02.002) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

The amino-terminal peptide domain of procollagen is cleaved and released into plasma. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1527-1528DOI: (10.1016/j.jtcvs.2016.02.002) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions