Volume 126, Issue 2, Pages (February 2004)

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Volume 126, Issue 2, Pages 414-424 (February 2004) Association of antibody responses to microbial antigens and complications of small bowel Crohn’s disease William S. Mow, Eric A. Vasiliauskas, Ying-Chao Lin, Phillip R. Fleshner, Konstantinos A. Papadakis, Kent D. Taylor, Carol J. Landers, Maria T. Abreu-Martin, Jerome I. Rotter, Huiying Yang, Stephan R. Targan Gastroenterology Volume 126, Issue 2, Pages 414-424 (February 2004) DOI: 10.1053/j.gastro.2003.11.015

Figure 1 Scatter graphs of the level of serum reactivity toward microbial antigens and autoantigens in this cohort: IgA I2 (A ), IgA OmpC (B), IgA ASCA (C ), IgG ASCA (D), and ANCA (E ). In each panel, the gray zone indicates the negatives. (○) I2-, OmpC-, ASCA-, and pANCA-positive samples. Note that the right side of panel E represents ANCA-positive samples with a cytoplasmic indirect immunofluorescent (IIF) staining pattern, whereas the left side of panel E represents a perinuclear staining pattern. Gastroenterology 2004 126, 414-424DOI: (10.1053/j.gastro.2003.11.015)

Figure 2 Relationship between microbial marker antibodies in this CD cohort by presence vs. absence. The percentage of patients positive for each marker, any combination of 2 markers, and all markers is shown (n = 303). Gastroenterology 2004 126, 414-424DOI: (10.1053/j.gastro.2003.11.015)

Figure 3 There were no significant changes in serological responses toward microbial antigens and autoantigens after small bowel surgery (time 0) in 26 patients with at least 1 sequential follow-up analysis ≥6 months after operation. Hashed lines represent the demarcation between positive and negative values. Gastroenterology 2004 126, 414-424DOI: (10.1053/j.gastro.2003.11.015)

Figure 4 Quartile analysis of the CD cohort for the 3 tested microbial antigens (I2, OmpC, and ASCA). The population was subdivided into 4 quartiles by I2 (top left), OmpC (middle left), and ASCA (bottom left) binding levels. Quartile sums were calculated by the addition of each individual’s quartile values for each microbial antigen (range, 3–12). Patients with the lowest level of reactivity toward all 3 antigens had a quartile sum score of 3, and patients with the highest level of antibody reactivity toward all 3 had a quartile sum score of 12. The distribution of quartile sums is shown (right). Values for binding levels are in enzyme-linked immunosorbent assay units. Gastroenterology 2004 126, 414-424DOI: (10.1053/j.gastro.2003.11.015)

Figure 5 The frequency of complicated small bowel disease increased with antibody reactivity, as represented by the quartile sum score (∗negative P trend). Patients with the highest level of antibody reactivity toward all 3 microbial antigens had the highest association with complicated small bowel disease phenotypes. Gastroenterology 2004 126, 414-424DOI: (10.1053/j.gastro.2003.11.015)