Drosophilosophical: Re-thinking Adaptive Immunity in the Fly

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Drosophilosophical: Re-thinking Adaptive Immunity in the Fly Cara West, Neal Silverman Cell Volume 169, Issue 2, Pages 188-190 (April 2017) DOI: 10.1016/j.cell.2017.03.032 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Parallels between the Antiviral Responses of Flies and Mammals Upon primary infection, both flies and mammals utilize non-germline-encoded DNA to produce soluble immune effectors. In flies, vDNA is derived from dsRNA intermediates produced during infection and engulfed by circulating haemocytes. In mammals, B cells activate class switch recombination to produce novel circulated antibodies. Immune effectors are then disseminated to provide long-lasting protection. In flies, vDNAs are used as templates for production of secondary viral siRNAs (vsRNAs), which are packaged into exosomes and excreted. In naive cells, these vsRNAs are loaded onto an RNA-induced silencing complex (RISCs) to provide protection. In mammals, antibodies are produced from plasma cells and provide protection through a variety of mechanisms. Cell 2017 169, 188-190DOI: (10.1016/j.cell.2017.03.032) Copyright © 2017 Elsevier Inc. Terms and Conditions